Bioactive triterpenoids from Lantana camara showing anti-inflammatory activities in vitro and in vivo

被引：24

作者：

Wu, Peng ^{[1
,2
]}

Song, Ziteng ^{[1
,2
]}

Wang, Xuelian ^{[1
,2
]}

Li, Ying ^{[1
,2
]}

Li, Yuhao ^{[3
]}

Cui, Jianlin ^{[3
]}

Tuerhong, Muhetaer ^{[4
]}

Jin, Da-Qing ^{[3
]}

Abudukeremu, Munira ^{[4
]}

Lee, Dongho ^{[5
]}

Xu, Jing ^{[1
,2
]}

Guo, Yuanqiang ^{[1
,2
,6
]}

机构：

[1] Nankai Univ, Coll Pharm, Tianjin Key Lab Mol Drug Res, State Key Lab Med Chem Biol, Tianjin 300050, Peoples R China

[2] Nankai Univ, Drug Discovery Ctr Infect Dis, Tianjin 300050, Peoples R China

[3] Nankai Univ, Sch Med, Tianjin 300071, Peoples R China

[4] Kashgar Univ, Coll Chem & Environm Sci, Lab Xinjiang Nat Med & Edible Plant Resources Che, Kashgar 844000, Peoples R China

[5] Korea Univ, Coll Life Sci & Biotechnol, Dept Biosyst & Biotechnol, Seoul 136713, South Korea

[6] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China

来源：

BIOORGANIC CHEMISTRY | 2020年 / 101卷

基金：

中国国家自然科学基金;

关键词：

Euphane triterpenoids; Anti-inflammatory properties; Molecular docking; Zebrafish model; Lantana camara; ANTI-NEUROINFLAMMATORY AGENTS; PENTACYCLIC TRITERPENOIDS; AERIAL PARTS; INHIBITORY-ACTIVITIES; NATURAL-PRODUCTS; ACID; CONSTITUENTS; INFLAMMATION; LIMONOIDS; LEAVES;

D O I：

10.1016/j.bioorg.2020.104004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bioactive natural products play an important role in the research and development of new drugs. In our search for bioactive natural substances as potential lead compounds for inflammation, four new (1-4) and six known (6-10) triterpenoids were acquired from Lantana camara. Using NMR and MS techniques and electronic circular dichroism (ECD) calculations, these isolates were characterized and the new compounds (1-4) were found to be euphane-type triterpenoids. The in vitro anti-inflammatory effects of all the isolates were evaluated and the more bioactive compounds were selected for the investigation of preliminary mechanism using molecular docking and Western blotting experiments, as well as the in vivo anti-inflammatory evaluation using a zebrafish model.

引用

页数：10

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