共 123 条
Nonalcoholic steatohepatitis: risk factors and diagnosis
被引:28
作者:

Adams, Leon A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Western Australia, Sch Med & Pharmacol, Sir Charles Gairdner Hosp Unit, Nedlands, WA 6009, Australia Cleveland Clin, Dept Cell Biol & Pediat Gastroenterol, Cleveland, OH 44195 USA

Feldstein, Ariel E.
论文数: 0 引用数: 0
h-index: 0
机构:
Cleveland Clin, Dept Cell Biol & Pediat Gastroenterol, Cleveland, OH 44195 USA Cleveland Clin, Dept Cell Biol & Pediat Gastroenterol, Cleveland, OH 44195 USA
机构:
[1] Cleveland Clin, Dept Cell Biol & Pediat Gastroenterol, Cleveland, OH 44195 USA
[2] Univ Western Australia, Sch Med & Pharmacol, Sir Charles Gairdner Hosp Unit, Nedlands, WA 6009, Australia
关键词:
cirrhosis;
cytokeratin-18;
diabetes;
insulin resistance;
liver biopsy;
nonalcoholic steatohepatitis;
obesity;
FATTY LIVER-DISEASE;
CLINICAL SCORING SYSTEM;
TERM-FOLLOW-UP;
INSULIN-RESISTANCE;
HEPATOCELLULAR-CARCINOMA;
LIPID-PEROXIDATION;
OBESE-PATIENTS;
NONINVASIVE BIOMARKER;
HISTOLOGIC SPECTRUM;
PLASMA ADIPONECTIN;
D O I:
10.1586/EGH.10.56
中图分类号:
R57 [消化系及腹部疾病];
学科分类号:
摘要:
Nonalcoholic steatohepatitis (NASH) represents the progressive form of nonalcoholic fatty liver disease with greater potential to lead to liver-related morbidity and mortality. Diagnosing NASH mandates more intensive clinical management and consideration for clinical trials. Currently, the diagnosis of NASH requires a liver biopsy, which is invasive, with drawbacks in sampling and interpretation error. Clinical risk factors for NASH include diabetes and the metabolic syndrome; however, these are not sufficiently predictive of the condition by themselves. Routine liver aminotransaminase levels are not reliable; however, novel plasma hepatocyte apoptosis markers, either alone or in combination with clinical risk factors, are potential noninvasive diagnostic tools for the future.
引用
收藏
页码:623 / 635
页数:13
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机构:
Cleveland Clin, Dept Gen Surg, Cleveland, OH 44106 USA Cleveland Clin, Dept Endocrinol, Cleveland, OH 44106 USA

Kashyap, Sangeeta R.
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Cleveland Clin, Dept Endocrinol, Cleveland, OH 44106 USA Cleveland Clin, Dept Endocrinol, Cleveland, OH 44106 USA

Lopez, Rocio
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机构: Cleveland Clin, Dept Endocrinol, Cleveland, OH 44106 USA

Hazen, Stanley L.
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机构:
Cleveland Clin, Dept Cell Biol, Cleveland, OH 44106 USA
Cleveland Clin, Ctr Cardiovasc Diagnost & Prevent, Cleveland, OH 44106 USA Cleveland Clin, Dept Endocrinol, Cleveland, OH 44106 USA

Feldstein, Ariel E.
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Cleveland Clin, Dept Pediat Gastroenterol, Cleveland, OH 44106 USA
Cleveland Clin, Dept Cell Biol, Cleveland, OH 44106 USA
Cleveland Clin, Ctr Cardiovasc Diagnost & Prevent, Cleveland, OH 44106 USA Cleveland Clin, Dept Endocrinol, Cleveland, OH 44106 USA