Nonalcoholic steatohepatitis: risk factors and diagnosis

被引：28

作者：

Adams, Leon A. ^{[2
]}

Feldstein, Ariel E. ^{[1
]}

机构：

[1] Cleveland Clin, Dept Cell Biol & Pediat Gastroenterol, Cleveland, OH 44195 USA

[2] Univ Western Australia, Sch Med & Pharmacol, Sir Charles Gairdner Hosp Unit, Nedlands, WA 6009, Australia

来源：

EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY | 2010年 / 4卷 / 05期

关键词：

cirrhosis; cytokeratin-18; diabetes; insulin resistance; liver biopsy; nonalcoholic steatohepatitis; obesity; FATTY LIVER-DISEASE; CLINICAL SCORING SYSTEM; TERM-FOLLOW-UP; INSULIN-RESISTANCE; HEPATOCELLULAR-CARCINOMA; LIPID-PEROXIDATION; OBESE-PATIENTS; NONINVASIVE BIOMARKER; HISTOLOGIC SPECTRUM; PLASMA ADIPONECTIN;

D O I：

10.1586/EGH.10.56

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Nonalcoholic steatohepatitis (NASH) represents the progressive form of nonalcoholic fatty liver disease with greater potential to lead to liver-related morbidity and mortality. Diagnosing NASH mandates more intensive clinical management and consideration for clinical trials. Currently, the diagnosis of NASH requires a liver biopsy, which is invasive, with drawbacks in sampling and interpretation error. Clinical risk factors for NASH include diabetes and the metabolic syndrome; however, these are not sufficiently predictive of the condition by themselves. Routine liver aminotransaminase levels are not reliable; however, novel plasma hepatocyte apoptosis markers, either alone or in combination with clinical risk factors, are potential noninvasive diagnostic tools for the future.

引用

页码：623 / 635

页数：13

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