The Role of Epigenetic Regulation in Diabetes and Its Complications

被引：2
作者：
Ling Hong-Yan [2 ,3 ]
Hu Bi [2 ]
Feng Shui-Dong [4 ]
Liao Duan-Fang [1 ]
Wen Ge-Bo [5 ]
机构：
[1] Hunan Univ Chinese Med, Sch Pharm, Changsha 410208, Hunan, Peoples R China
[2] Univ S China, Dept Physiol, Sch Med, Hengyang 421001, Peoples R China
[3] Univ S China, Ctr Basic Med Postdoctoral Studies, Hengyang 421001, Peoples R China
[4] Univ S China, Dept Epidemiol, Sch Publ Hlth, Hengyang 421001, Peoples R China
[5] Univ S China, Inst Clin Res, Affiliated Hosp 1, Hengyang 421001, Peoples R China
来源：
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS | 2012年 / 39卷 / 01期
基金：
中国国家自然科学基金;
关键词：
epigenetic regulation; diabetes; diabetic complications; HISTONE DEACETYLASE INHIBITORS; DNA METHYLATION; GENE-EXPRESSION; IN-VIVO; CHANNEL EXPRESSION; METABOLIC SYNDROME; INSULIN-SECRETION; COACTIVATOR P300; LIPID-METABOLISM; COLLECTING DUCT;
D O I：
10.3724/SP.J.1206.2011.00230
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Epigenetics indicates the heritable changes in gene expression without nucleotide sequence variation. The process of epigenetic regulation is very complex, which mainly includes DNA methylations, histone modifications and miRNA. Diabetes is a chronic metabolic disease accompanied with macrovascular and microvascular complications. The development of diabetes not only depends on genetic factors, but also is regulated by epigenetic regulation. Therefore, further exploration into epigenetic regulation will provide new ideas and methods to the prevention and treatment for diabetes and its complications.
引用
收藏
页码：14 / 21
页数：8
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