Use of mesenchymal stem cells to enhance bone formation around revision hip replacements

被引:38
作者
Korda, Michelle [1 ]
Blunn, Gordon [1 ]
Goodship, Allen [1 ,2 ]
Hua, Jia [1 ]
机构
[1] UCL, Royal Natl Orthopaed Hosp Trust, Inst Orthopaed & Musculo Skeletal Sci, Ctr Biomed Engn, Stanmore H47 4LP, Middx, England
[2] Univ London Royal Vet Coll, S Mymms, Herts, England
基金
英国生物技术与生命科学研究理事会;
关键词
revision total hip replacements; mesenchymal stem cells; tissue engineering; osteolysis; new bone formation;
D O I
10.1002/jor.20598
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
Tissue engineering approaches to regenerate bone stock in revision total hip replacements could enhance the longevity of the implant and benefit the quality of the patient's life. This study investigated the impaction of allograft with mesenchymal stem cells in an ovine hip hemiarthroplasty model. In total, 10 sheep were divided into two groups with 5 sheep in each group. The groups were: 1) mesenchymal stem cells mixed with allograft; 2) allograft only as a control. Ground reaction force was assessed for limb function and showed that there was no significant difference in the recovery for animals in different groups. The amount of bone regenerated around the hip replacement was assessed using un-decalcified histology. The results showed that the stem cell group generated significantly more new bone at the implant-allograft interface and within the graft than the control group. The results from this study indicate that the use of stem cells on an allograft scaffold increases bone formation indicating that the use of stem cells for revision hip arthroplasty may be beneficial for patients undergoing revision surgery where the bone stock is compromised. (C) 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.
引用
收藏
页码:880 / 885
页数:6
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