Wnt signaling in macrophages: Augmenting and inhibiting mycobacteria-induced inflammatory responses

被引：147

作者：

Schaale, Kolja ^{[1
]}

Neumann, Jan ^{[1
]}

Schneider, Dagmar ^{[1
]}

Ehlers, Stefan ^{[2
,3
]}

Reiling, Norbert ^{[1
]}

机构：

[1] Leibniz Ctr Med & Biosci, Div Microbial Interface Biol, Res Ctr Borstel, D-23845 Borstel, Germany

[2] Leibniz Ctr Med & Biosci, Sect Microbial Inflammat Res, Res Ctr Borstel, D-23845 Borstel, Germany

[3] Univ Kiel, D-24118 Kiel, Germany

来源：

EUROPEAN JOURNAL OF CELL BIOLOGY | 2011年 / 90卷 / 6-7期

关键词：

Wnt signaling; Macrophage; Mycobacteria; Infection; Inflammation; GLYCOGEN-SYNTHASE KINASE-3; BETA-CATENIN; PROTEIN-KINASE; RHEUMATOID-ARTHRITIS; EPITHELIAL-CELLS; MOUSE MODELS; TNF-ALPHA; PATHWAY; ACTIVATION; EXPRESSION;

D O I：

10.1016/j.ejcb.2010.11.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Wnt proteins are secreted, palmitoylated glycoproteins with multiple functions in cell proliferation and migration as well as tissue organization. They are best known for their role in embryonic development and tissue homeostasis. In the last years, Wnt signaling was also shown to be involved in the regulation of inflammatory processes: Wnt5a is induced in human macrophages in response to mycobacteria and conserved bacterial structures and contributes to the regulation of pro-inflammatory cytokines via its receptor Frizzled (Fzd) 5. Wnt5a is also induced in other infectious and inflammatory diseases such as tuberculosis, sepsis, psoriasis, rheumatoid arthritis and atherosclerosis. In contrast, Wnt3a, a ligand of Fzd1, is constitutively expressed by bronchial epithelial cells and mediates anti-inflammatory effects on mycobacteria-infected macrophages via the Wnt/beta-Catenin signaling pathway. This pathway suppresses the activity of GSK3beta, a well known regulator of NF-kappaB-dependent gene transcription. Here we review recent data on immunomodulatory activities of Wnt proteins. Additional experiments using exogenous Wnt homologs further support the notion that TLR/NF-kappaB and Wnt signaling are functionally interconnected. (C) 2010 Elsevier GmbH. All rights reserved.

引用

页码：553 / 559

页数：7

共 65 条

[1] Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by β-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT [J].