Inhibition of 2-oxoglutarate dehydrogenase complex by free fatty acids

被引：0
|
作者：
Ostrovtsova, SA
机构：
来源：
MEDICAL SCIENCE RESEARCH | 1996年 / 24卷 / 09期
关键词：
oxoglutarate dehydrogenase complex; heart; fatty acids; Krebs cycle;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Fatty acids, along with carbohydrates, are the main sources of fuel for the Krebs cycle in the form of acetyl-CoA. They have a regulatory role in liver and heart. We studied the possibility of regulation of the activity of 2-oxoglutarate dehydrogenase complex (OGDC) and its first component, oxoglutarate dehydrogenase (OGD), in bovine heart by free long chain fatty acids. The results indicate that oleate plays a significant role in OGDC and OGD function by changing kinetic parameters of the complex. This fatty acid inhibits oxoglutarate dehydrogenase complex activity with 2-oxoglutarate by increasing [S](0.5) values.
引用
收藏
页码：625 / 627
页数：3
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