Reversible, reagentless solubility changes in phosphatidylcholine-stabilized gold nanoparticles

被引：17

作者：

Mackiewicz, Marilyn R. ^{[1
]}

Ayres, Benjamin R. ^{[1
]}

Reed, Scott M. ^{[1
]}

机构：

[1] Portland State Univ, Dept Chem, Portland, OR 97207 USA

来源：

NANOTECHNOLOGY | 2008年 / 19卷 / 11期

关键词：

D O I：

10.1088/0957-4484/19/11/115607

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Phosphatidylcholine (PC) is a versatile ligand for synthesizing gold nanoparticles that are soluble in either organic or aqueous media. Here we report a novel route to organic-soluble, PC-stabilized gold nanoparticles that can be re-suspended in water after removal of the organic solvent. Similarly, we show that PC-stabilized gold nanoparticles synthesized in water can be re-suspended in organic solvents after complete removal of water. Without complete removal of the solvent, the nanoparticles retain their original solubility and do not phase transfer. This change in solvent preference from organic to aqueous and vice versa without the use of an additional phase transfer reagent is novel, visually striking, and of utility for synthetic modification of nanoparticles. This approach allows chemical reactions to be performed on nanoparticles in organic solvents followed by conversion of the products to water-soluble materials. A narrow distribution of PC-stabilized gold nanoparticles was obtained after phase transfer to water as characterized by UV-visible (UV-vis) spectroscopy and transmission electron microscopy (TEM), demonstrating that the narrow distribution obtained from the organic synthesis is retained after transfer to water. This method produces water-soluble nanoparticles with a narrower dispersity than is possible with direct aqueous synthesis.

引用

页数：6

共 65 条

[11] Size-dependent phase transfer of gold nanoparticles from water into toluene by tetraoctylammonium cations: A wholly electrostatic interaction [J].

Cheng, WL ;

Wang, E .

JOURNAL OF PHYSICAL CHEMISTRY B, 2004, 108 (01) :24-26

[12] Controlled growth of gold nanoparticles in AOT/C12E4/isooctane mixed reverse micelles [J].

Chiang, CL .

JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2001, 239 (02) :334-341

[13] Synthesis of mixed monolayer-protected gold clusters from thiol mixtures: Variation in the tail group, chain length, and solvent [J].

Choo, H ;

Cutler, E ;

Shon, YS .

LANGMUIR, 2003, 19 (20) :8555-8559

[14] Gold nanoparticles are taken up by human cells but do not cause acute cytotoxicity [J].

Connor, EE ;

Mwamuka, J ;

Gole, A ;

Murphy, CJ ;

Wyatt, MD .

SMALL, 2005, 1 (03) :325-327

[15] Effect of cationic liposome composition on in vitro cytotoxicity and protective effect on carried DNA [J].

Cortesi, R ;

Esposito, E ;

Menegatti, E ;

Gambari, R ;

Nastruzzi, C .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1996, 139 (1-2) :69-78

[16] Toward greener nanosynthesis [J].

Dahl, Jennifer A. ;

Maddux, Bettye L. S. ;

Hutchison, James E. .

CHEMICAL REVIEWS, 2007, 107 (06) :2228-2269

[17] Silane ligand exchange to make hydrophobic superparamagnetic nanoparticles water-dispersible [J].

De Palma, Randy ;

Peeters, Sara ;

Van Bael, Margriet J. ;

Van den Rul, Heidi ;

Bonroy, Kristien ;

Laureyn, Wim ;

Mullens, Jules ;

Borghs, Gustaaf ;

Maes, Guido .

CHEMISTRY OF MATERIALS, 2007, 19 (07) :1821-1831

[18]

DEBIN H, 1998, CHINESE SCI BULL, V43, P789

[19] A versatile strategy for quantum dot ligand exchange [J].

Dubois, Fabien ;

Mahler, Benoit ;

Dubertret, Benoit ;

Doris, Eric ;

Mioskowski, Charles .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (03) :482-483

[20] Plasmon scattering from a single gold nanoparticle collected through an optical fiber [J].

Eah, SK ;

Jaeger, HM ;

Scherer, NF ;

Wiederrecht, GP ;

Lin, XM .

APPLIED PHYSICS LETTERS, 2005, 86 (03) :1-3

← 1 2 3 4 5 6 7 →