Visible Light-Promoted Radical Relay Cyclization/C-C Bond Formation of N-Allylbromodifluoroacetamides with Quinoxalin-2(1H)-ones

被引：28

作者：

Ye, Zhi-Peng ^{[1
]}

Liu, Fang ^{[1
]}

Duan, Xin-Yu ^{[1
]}

Gao, Jie ^{[1
]}

Guan, Jian-Ping ^{[1
]}

Xiao, Jun-An ^{[2
]}

Xiang, Hao-Yue ^{[1
]}

Chen, Kai ^{[1
]}

Yang, Hua ^{[1
]}

机构：

[1] Cent South Univ, Coll Chem & Chem Engn, Changsha 410083, Peoples R China

[2] Nanning Normal Univ, Coll Chem & Mat Sci, Nanning 530001, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 86卷 / 23期

基金：

中国国家自然科学基金;

关键词：

ARYL ACYL PEROXIDES; BIOLOGICAL EVALUATION; H ALKYLATION; INHIBITORS; METAL; AMINODIFLUOROALKYLATION; DERIVATIVES; ARYLATION; EFFICIENT; DESIGN;

D O I：

10.1021/acs.joc.1c02285

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A visible light-promoted radical relay of N-allylbromodifluoroacetamide with quinoxalin-2(1H)-ones was developed in which 5-exo-trig cyclization and C-C bond formation were involved. This protocol was performed under mild conditions to facilely offer a variety of hybrid molecules bearing both quinoxalin-2(1H)-one and 3,3-difluoro-gamma-lactam motifs. These prepared novel skeletons would expand the accessible chemical space for structurally complex heterocycles with potential biological activities.

引用

页码：17173 / 17183

页数：11

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