New Insights Into the Pharmacokinetics of Vancomycin After Oral and Intravenous Administration: An Investigation in Beagle Dogs

被引：6

作者：

Sauter, Max ^{[1
,2
]}

Uhl, Philipp ^{[1
,2
]}

Meid, Andreas D. ^{[1
,2
]}

Mikus, Gerd ^{[1
,2
]}

Burhenne, Juergen ^{[1
,2
]}

Haefeli, Walter E. ^{[1
,2
]}

机构：

[1] Heidelberg Univ Hosp, Dept Clin Pharmacol & Pharmacoepidemiol, Neuenheimer Feld 410, D-69120 Heidelberg, Germany

[2] German Ctr Infect Res DZIF, Heidelberg Partner Site, Neuenheimer Feld 410, D-69120 Heidelberg, Germany

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 2020年 / 109卷 / 06期

关键词：

vancomycin; pharmacokinetics; peroral; bioavailability; dogs; SYSTEMIC ABSORPTION; INTRACOLONIC VANCOMYCIN; PATIENT; ACCUMULATION; GENTAMICIN; TOBRAMYCIN; COLITIS;

D O I：

10.1016/j.xphs.2020.03.012

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Intestinal absorption of orally administered peptides is often negligible because one or more key requirements for successful absorption (water solubility, peptic resistance, mucosal permeation) are not met. Due to its high water solubility and stability in the gastro-intestinal tract, vancomycin is an ideal model peptide for evaluating the factors influencing the critical step of mucosal permeation. Therefore, to support formulation development for the systemic oral delivery of peptide therapeutics, we investigated the pharmacokinetics of vancomycin in beagle dogs after intravenous and oral administration comparing enteric encapsulated drug to the drug in solution, which revealed mean absolute bio-availabilities of 0.27% and 1.66%, respectively. Additionally, in depth pharmacokinetic analyses of intravenously administered vancomycin revealed a deep compartment slowly releasing the compound over many hours into the blood. (C) 2020 American Pharmacists Association (R). Published by Elsevier Inc. All rights reserved.

引用

页码：2090 / 2094

页数：5

共 39 条

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