Competing for the Clamp: Promoting RNA Polymerase Processivity and Managing the Transition from Initiation to Elongation

被引：15
|
作者：
Hartzog, Grant A. [1 ]
Kaplan, Craig D. [2 ]
机构：
[1] Univ Calif Santa Cruz, Dept Mol Cell & Dev Biol, Santa Cruz, CA 95064 USA
[2] Texas A&M Univ, Dept Biochem & Biophys, College Stn, TX 77843 USA
来源：
MOLECULAR CELL | 2011年 / 43卷 / 02期
基金：
英国生物技术与生命科学研究理事会;
关键词：
TRANSCRIPTION ELONGATION; COMPLEX; RFAH;
D O I：
10.1016/j.molcel.2011.07.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Transcription elongation factor NusG/Spt5 spans the central cleft of RNA polymerase and functionally competes with transcription initiation factors. This work highlights the RNA polymerase clamp as a target for regulation and points to dynamic interactions between initiation and elongation machineries.
引用
收藏
页码：161 / 163
页数：3
相关论文
共 50 条
  • [1] The transition from initiation to elongation by RNA polymerase II
    Luse, DS
    Samkurashvili, I
    COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1998, 63 : 289 - 300
  • [2] The transition from initiation to elongation in T7 RNA polymerase
    Esposito, EA
    Kowalski, RT
    Gong, P
    Martin, CT
    BIOPHYSICAL JOURNAL, 2004, 86 (01) : 417A - 417A
  • [3] Initiation, elongation, and processivity of carboxyl-terminal mutants of T7 RNA polymerase
    Gardner, LP
    Mookhtiar, KA
    Coleman, JE
    BIOCHEMISTRY, 1997, 36 (10) : 2908 - 2918
  • [4] Transcripts that increase the processivity and elongation rate of RNA polymerase
    King, RA
    BanikMaiti, S
    Jin, DJ
    Weisberg, RA
    CELL, 1996, 87 (05) : 893 - 903
  • [5] The structure of a transcribing T7 RNA polymerase in transition from initiation to elongation
    Durniak, Kimberly J.
    Bailey, Scott
    Steitz, Thomas A.
    SCIENCE, 2008, 322 (5901) : 553 - 557
  • [6] Real-time observation of the transition from transcription initiation to elongation of the RNA polymerase
    Tang, Guo-Qing
    Roy, Rahul
    Bandwar, Rajiv P.
    Ha, Taekjip
    Patel, Smita S.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (52) : 22175 - 22180
  • [7] RNA synthesis by the brome mosaic virus RNA-dependent RNA polymerase: Transition from initiation to elongation
    Sun, JH
    Kao, CC
    VIROLOGY, 1997, 233 (01) : 63 - 73
  • [8] Structural changes in the RNA polymerase II transcription complex during transition from initiation to elongation
    Samkurashvili, I
    Luse, DS
    MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (09) : 5343 - 5354
  • [9] The interaction between bacterial transcription factors and RNA polymerase during the transition from initiation to elongation
    Yang, Xiao
    Lewis, Peter J.
    TRANSCRIPTION-AUSTIN, 2010, 1 (02): : 66 - 69
  • [10] Structural basis for the transition from initiation to elongation transcription in T7 RNA polymerase
    Yin, YW
    Steitz, TA
    SCIENCE, 2002, 298 (5597) : 1387 - 1395
12345