Heterocycle Synthesis via Direct C-H/N-H Coupling

被引：370

作者：

Nadres, Enrico T. ^{[1
]}

Daugulis, Olafs ^{[1
]}

机构：

[1] Univ Houston, Dept Chem, Houston, TX 77204 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2012年 / 134卷 / 01期

关键词：

N BOND FORMATION; CATALYZED ARYLATION; AMINATION; PALLADIUM; FUNCTIONALIZATION; ACETOXYLATION; DERIVATIVES; ACTIVATION; AMIDATION; ROUTE;

D O I：

10.1021/ja210959p

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A method for five- and six-membered heterocycle formation by palladium-catalyzed C-H/N-H coupling is presented. The method employs a picolinamide directing group, PhI(OAc)(2) oxidant, and toluene solvent at 80-120 degrees C. Cyclization is effective for sp(2) as well as aliphatic and benzylic sp(3) C-H bonds.

引用

页码：7 / 10

页数：4

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