Heterocycle Synthesis via Direct C-H/N-H Coupling

被引：370
|
作者：
Nadres, Enrico T. [1 ]
Daugulis, Olafs [1 ]
机构：
[1] Univ Houston, Dept Chem, Houston, TX 77204 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2012年 / 134卷 / 01期
关键词：
N BOND FORMATION; CATALYZED ARYLATION; AMINATION; PALLADIUM; FUNCTIONALIZATION; ACETOXYLATION; DERIVATIVES; ACTIVATION; AMIDATION; ROUTE;
D O I：
10.1021/ja210959p
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A method for five- and six-membered heterocycle formation by palladium-catalyzed C-H/N-H coupling is presented. The method employs a picolinamide directing group, PhI(OAc)(2) oxidant, and toluene solvent at 80-120 degrees C. Cyclization is effective for sp(2) as well as aliphatic and benzylic sp(3) C-H bonds.
引用
收藏
页码：7 / 10
页数：4
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