IMMUNOLOGY PKR-Dependent Inflammatory Signals

被引：80

作者：

Kang, Rui ^{[1
]}

Tang, Daolin ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Surg, Univ Pittsburgh Canc Inst, Pittsburgh, PA 15213 USA

来源：

SCIENCE SIGNALING | 2012年 / 5卷 / 247期

关键词：

PROTEIN-KINASE PKR; KAPPA-B KINASE; HMGB1; RELEASE; REGULATES AUTOPHAGY; ACTIVATION; APOPTOSIS; INTERFERON; IMMUNITY; INFLAMMASOMES; IL-1-BETA;

D O I：

10.1126/scisignal.2003511

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Double-stranded RNA-dependent protein kinase (PKR) is implicated in inflammation and immune dysfunction through its regulation of mitogen-activated protein kinases, interferon regulatory factor 3, nuclear factor kappa B, apoptosis, and autophagy pathways. A study shows that PKR is also required for the activation of inflammasomes and the subsequent release of high-mobility group box 1 (HMGB1) protein, a proinflammatory cytokine. Thus, the cell stress kinase PKR has multifaceted roles in the regulation of inflammatory immune responses, and PKR and HMGB1 are attractive targets for inflammasome-associated diseases.

引用

页数：3

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