Enantioselective Conjugate Addition of Nitroalkanes to Alkylidenemalonates Promoted by Thiourea-Based Bifunctional Organocatalysts

被引：24
|
作者：
Chiarucci, Michel [1 ]
Lombardo, Marco [1 ]
Trombini, Claudio [1 ]
Quintavalla, Arianna [1 ]
机构：
[1] Univ Bologna, Dipartimento Chim G Ciamician, I-40126 Bologna, Italy
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2012年 / 354卷 / 2-3期
关键词：
alkylidenemalonates; asymmetric organocatalysis; bifunctional thioureas; Michael reaction; nitro compounds; ASYMMETRIC MICHAEL ADDITION; 1,3-DICARBONYL COMPOUNDS; ALPHA; BETA-UNSATURATED IMIDES; 1,4-ADDITION;
D O I：
10.1002/adsc.201100732
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Cinchona alkaloids-derived bifunctional thioureas efficiently catalyse the enantioselective conjugate addition of nitroalkanes to alkylidenemalonates with syn-diastereopreference, opening a route to the synthesis of optically active ?-amino acid derivatives.
引用
收藏
页码：364 / 370
页数：7
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