pH Dependent Spontaneous Growth of Ellagic Acid Assemblies for Targeting HeLa Cells

被引：8

作者：

Barnaby, Stacey N. ^{[1
]}

Yu, Samantha M. ^{[1
]}

Tsiola, Areti ^{[2
]}

Fath, Karl R. ^{[2
,3
]}

Banerjee, Ipsita A. ^{[1
]}

机构：

[1] Fordham Univ, Dept Chem, Bronx, NY 10458 USA

[2] CUNY Queens Coll, Dept Biol, Flushing, NY 11367 USA

[3] CUNY, Grad Ctr, New York, NY 10016 USA

来源：

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | 2011年 / 11卷 / 09期

关键词：

Ellagic Acid Assemblies; Growth; HeLa Cancer Cells Imaging; Therapy; DRUG-DELIVERY; CANCER-CELLS; IN-VITRO; NANOPARTICLES; POLYPHENOLS; ANTIOXIDANT; CRYSTAL; INHIBITION; MOLECULES; EXTRACTS;

D O I：

10.1166/jnn.2011.4709

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein, we have studied the self-assembly and the spontaneous growth of microassemblies of the plant polyphenol ellagic acid for He La cancer cell imaging and therapy. The growth of the assemblies was studied at varying pH over time. It was found that initially microspheres were formed which gradually transformed into microfibers via nucleation and polymerization process. The optimum growth of microfibers was found to be in the pH range of 6-8. We have shown that the microfibers successfully adhered to the He La cell membranes and inhibited their proliferation. This biological approach, using assemblies derived from plant polyphenols, may be used for direct cellular drug delivery and may potentially help develop a simple and economical method to create building blocks with desired properties for a new generation of sensors, bioimaging and drug delivery systems.

引用

页码：7579 / 7586

页数：8

共 57 条

[1] High-performance liquid chromatographic determination with photodiode array detection of ellagic acid in fresh and processed fruits [J].