Natural and induced immunization against CCL20 ameliorate experimental autoimmune encephalitis and may confer protection against multiple sclerosis

被引：8

作者：

Abraham, Michal ^{[2
]}

Karni, Arnon ^{[3
,4
]}

Mausner-Fainberg, Karin ^{[3
]}

Weiss, Ido D. ^{[1
]}

Peled, Amnon ^{[1
,2
]}

机构：

[1] Hebrew Univ Hosp, Goldyne Savad Inst Gene Therapy, Jerusalem, Israel

[2] Biokine Therapeut Ltd, Ness Ziona, Israel

[3] Tel Aviv Sourasky Med Ctr, Dept Neurol, Neuroimmunol Lab, Tel Aviv, Israel

[4] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel

来源：

CLINICAL IMMUNOLOGY | 2017年 / 183卷

关键词：

CCR6; CCL20; Experimental autoimmune encephalomyelitis; Multiple sclerosis; Autoantibody; Protective autoimmunity; CENTRAL-NERVOUS-SYSTEM; CHEMOKINE RECEPTOR EXPRESSION; REGULATORY T-CELLS; TH17; CELLS; ENCEPHALOMYELITIS; CCR6; BETA; RECRUITMENT; DISEASE; LESIONS;

D O I：

10.1016/j.clim.2017.09.018

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Th-17 type immune response that occurs in multiple sclerosis (MS) is linked to CCR6-CCL20 interaction. We confirmed the dependency on CCR6 in EAE development. Vaccination of mice with hCCL20, but not mCCL20, produced anti-murine CCL20 and ameliorated EAE. The EAE clinical score negatively correlated with anti CCL20 levels. A beneficial effect was transferred by sera from hCCL20-immunized mice. Immunized mice with cyclic peptide that include a bacterial outer membrane protein A (ompA), that share homology sequence with hCCL20 produced anti CCL20, anti ompA and anti-cyclic peptide. Immunization of mice with ompA or the cyclic peptide ameliorated EAE. The cyclic peptide inhibited CCL20 activity in an adhesion assay. A significantly higher level of anti CCL20 were found in healthy individuals compared to RR-MS patients. There was no similar difference for anti-CXCL10. Natural or induced immunization against CCL20 confer protection against EAE and may be beneficial in MS. (C) 2017 Elsevier Inc. All rights reserved.

引用

页码：316 / 324

页数：9

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