Tumour-to-tumour metastasis from papillary thyroid carcinoma with BRAF mutation to lung adenocarcinoma with EGFR mutation: the utility of mutation-specific antibodies

被引:12
作者
Katsuya, Yuki [1 ,2 ]
Yoshida, Akihiko [1 ]
Watanabe, Shun-ichi [3 ]
Tsuta, Koji [1 ]
机构
[1] Natl Canc Ctr, Div Pathol & Clin Lab, Tokyo 1040045, Japan
[2] Natl Canc Ctr, Dept Thorac Oncol, Tokyo 1040045, Japan
[3] Natl Canc Ctr, Div Thorac Surg, Tokyo 1040045, Japan
关键词
gene mutation; immunohistochemistry; lung adenocarcinoma; papillary thyroid tumour; tumour-to-tumour metastasis; ADENOID CYSTIC CARCINOMA; CANCER METASTASIS;
D O I
10.1111/his.12643
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
AimsTumour-to-tumour metastasis is a rare event. The aim of this study is to demonstrate the utility of mutation-specific antibodies to prove the occurrence of metastatic papillary thyroid cancer donor into lung adenocarcinoma recipient. Methods and resultsWe report the case of an 80-year-old woman who had a papillary thyroid carcinoma with a v-raf murine sarcoma viral oncogene homologue B1 mutation that metastasized into a lungadenocarcinoma with an epidermal growth factor receptor mutation. Immunohistochemical analysis with mutation-specific antibodies not only clearly revealed two components, but also revealed their gene mutation statuses. ConclusionsAs a component of multimodal diagnostic tools, immunohistochemistry can avoid some pitfalls involved in the molecular diagnosis of complicated cases (such as our own) and can helptoensure that patients receive optimal treatments.
引用
收藏
页码:262 / 266
页数:5
相关论文
共 14 条
[1]  
Berent W., 1902, Zentralblatt fr allgemeine Pathologie und pathologische Anatomie, V13, P406
[2]   Pulmonar collision tumor: Metastatic adenoid cystic carcinoma and lung adenocarcinoma [J].
Blanco, M. ;
Garcia-Fontan, E. ;
Rios, J. ;
Rivo, J. E. ;
Fernandez-Martin, R. ;
Canizares, M. A. .
REVISTA PORTUGUESA DE PNEUMOLOGIA, 2012, 18 (01) :42-45
[3]   Tumor-to-tumor metastasis: Lung adenocarcinoma metastasizing to a follicular variant of papillary thyroid carcinoma [J].
Hashimoto, Kazuki ;
Yamamoto, Hidetaka ;
Nakano, Takafumi ;
Oyama, Minako ;
Shiratsuchi, Hideki ;
Nakashima, Torahiko ;
Tamiya, Sadafumi ;
Komune, Shizuo ;
Oda, Yoshinao .
PATHOLOGY INTERNATIONAL, 2011, 61 (07) :435-441
[4]   Papillary Carcinoma of Thyroid Metastatic to Adenocarcinoma In Situ of Lung: Report of an Unusual Case [J].
Kim, Kyoung Min ;
Kim, Yo Na ;
Chu, Hyun Hee ;
Jin, Heung Yong ;
Kim, Min Ho ;
Chung, Myoung Ja .
KOREAN JOURNAL OF PATHOLOGY, 2012, 46 (03) :282-286
[5]   Coexistence of EGFR with KRAS, or BRAF, or PIK3CA somatic mutations in lung cancer: a comprehensive mutation profiling from 5125 Chinese cohorts [J].
Li, S. ;
Li, L. ;
Zhu, Y. ;
Huang, C. ;
Qin, Y. ;
Liu, H. ;
Ren-Heidenreich, L. ;
Shi, B. ;
Ren, H. ;
Chu, X. ;
Kang, J. ;
Wang, W. ;
Xu, J. ;
Tang, K. ;
Yang, H. ;
Zheng, Y. ;
He, J. ;
Yu, G. ;
Liang, N. .
BRITISH JOURNAL OF CANCER, 2014, 110 (11) :2812-2820
[6]   Tumor-to-Tumor Metastasis: Maxillary Sinus Adenoid Cystic Carcinoma Metastasizing to Double Primary Lung Adenocarcinoma [J].
Lin, Wei-Yang ;
Hsu, Wen-Hu .
ANNALS OF THORACIC SURGERY, 2010, 90 (04) :E59-E61
[7]   Tumor-to-tumor metastasis from lung cancer: a clinicopathological postmortem study [J].
Matsukuma, Susumu ;
Kono, Takako ;
Takeo, Hiroaki ;
Hamakawa, Yusuke ;
Sato, Kimiya .
VIRCHOWS ARCHIV, 2013, 463 (04) :525-534
[8]  
MORIYA T, 1988, ARCH PATHOL LAB MED, V112, P286
[9]   2 PATIENTS WITH METASTASIS OF CANCER TO OTHER NEOPLASM - A THYROID-CARCINOMA METASTATIC TO A LUNG-CARCINOMA AND A GASTRIC-CARCINOMA METASTATIC TO A THYROID ADENOMA [J].
NONOMURA, A ;
MIZUKAMI, Y ;
SHIMIZU, J ;
WATANABE, Y ;
KAMIMURA, R ;
TAKASHIMA, T .
ENDOCRINE PATHOLOGY, 1994, 5 (04) :233-239
[10]   LUNG CANCER METASTASIS TO ADRENAL CORTICAL ADENOMAS [J].
ONUIGBO, WIB .
JOURNAL OF PATHOLOGY AND BACTERIOLOGY, 1963, 86 (02) :541-&