Processing and presentation of antigens by dendritic cells: implications for vaccines

被引：62
作者：
Bhardwaj, N [1 ]
机构：
[1] Rockefeller Univ, New York, NY 10021 USA
来源：
TRENDS IN MOLECULAR MEDICINE | 2001年 / 7卷 / 09期
关键词：
D O I：
10.1016/S1471-4914(01)02101-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Dendritic cells (DCs) are potent antigen-presenting cells that are specialized in initiation of T-cell immunity. DCs induce promising anti-tumor T-cell and clinical responses, apparently without significant toxicity. Under certain conditions, DCs even silence T-cell immune responses in vivo. This dual capacity to modulate the immune system uniquely positions DCs for the treatment of autoimmunity, cancer and chronic viral infections.
引用
收藏
页码：388 / 394
页数：7
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