Responders to vagus nerve stimulation (VNS) in refractory epilepsy have reduced interictal cortical synchronicity on scalp EEG

被引：80

作者：

Bodin, Clementine ^{[1
]}

Aubert, Sandrine ^{[1
]}

Daquin, Geraldine ^{[2
]}

Carron, Romain ^{[3
]}

Scavarda, Didier ^{[4
]}

McGonigal, Aileen ^{[1
]}

Bartolomei, Fabrice ^{[1
,5
]}

机构：

[1] CHU Timone, AP HP, Serv Neurophysiol Clin, F-13005 Marseille, France

[2] Hop Henri Gastaut, F-13009 Marseille, France

[3] CHU Timone, AP HP, Stereotact & Funct Neurosurg Dept, F-13005 Marseille, France

[4] CHU Timone, AP HP, Pediat Neurosurg Dept, F-13005 Marseille, France

[5] INSERM, Inst Neurosci Syst, UMR 1106, F-13258 Marseille, France

来源：

EPILEPSY RESEARCH | 2015年 / 113卷

关键词：

VNS; EEG; Functional connectivity; Synchrony; Epilepsy; FREQUENCIES; HZ;

D O I：

10.1016/j.eplepsyres.2015.03.018

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

EEG desynchronization has been proposed to be an important mechanism for antiepileptic effect of vagus nerve stimulation (VNS) but has never been clearly documented in human. The aim of this study was to evaluate impact of VNS on the synchronicity of interictal EEG rhythms. We estimated synchronization between scalp EEG signals using phase lag index (PLI) in 19 patients with chronic VNS therapy. We estimated changes in synchronization between ON and OFF phases and between responder (R) and non-responder (NR) patients. We found that R have a lower global level of synchronization (EEG broadband) than NR (p< 0.0001) In addition, ON periods were characterized by lower values in comparison with OFF periods (p< 0.001). R had significantly lower global synchronization levels in delta and alpha frequency bands (p<0.0001). Patients responding to VNS have thus a lower level of broadband EEG synchronization than non-responders. Estimating changes of synchronization level is thus a promising tool for predicting response to VNS. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：98 / 103

页数：6

共 15 条

[11] VAGUS NERVE-STIMULATION HAS NO EFFECT ON AWAKE EEG RHYTHMS IN HUMANS [J].

SALINSKY, MC ;

BURCHIEL, KJ .

EPILEPSIA, 1993, 34 (02) :299-304

[12] Vagus nerve stimulation for refractory epilepsy in children: More to VNS than seizure frequency reduction [J].

Shahwan, Amre ;

Bailey, Catherine ;

Maxiner, Wirginia ;

Harvey, A. Simon .

EPILEPSIA, 2009, 50 (05) :1220-1228

[13] Phase lag index: Assessment of functional connectivity from multi channel EEG and MEG with diminished bias from common sources [J].

Stam, Cornelis J. ;

Nolte, Guido ;

Daffertshofer, Andreas .

HUMAN BRAIN MAPPING, 2007, 28 (11) :1178-1193

[14] Scalp electrical recording during paralysis: Quantitative evidence that EEG frequencies above 20 Hz are contaminated by EMG [J].

Whithain, Emma M. ;

Pope, Kenneth J. ;

Fitzgibbon, Sean P. ;

Lewis, Trent ;

Clark, C. Richard ;

Loveless, Stephen ;

Broberg, Marita ;

Wallace, Angus ;

DeLosAngeles, Dylan ;

Lillie, Peter ;

Hardy, Andrew ;

Fronsko, Rik ;

Pulbrook, Alyson ;

Willoughby, John O. .

CLINICAL NEUROPHYSIOLOGY, 2007, 118 (08) :1877-1888

[15] Issues related to development of new antiseizure treatments [J].

Wilcox, Karen S. ;

Dixon-Salazar, Tracy ;

Sills, Graeme J. ;

Ben-Menachem, Elinor ;

White, H. Steve ;

Porter, Roger J. ;

Dichter, Marc A. ;

Moshe, Solomon L. ;

Noebels, Jeffrey L. ;

Privitera, Michael D. ;

Rogawski, Michael A. .

EPILEPSIA, 2013, 54 :24-34

← 1 2 →