A 1-week extension of a ketogenic diet provides a further decrease in myocardial 18F-FDG uptake and a high detectability of myocarditis with FDG-PET

被引:9
作者
Clement, Alexandra [1 ]
Boutley, Henri [1 ]
Poussier, Sylvain [1 ]
Pierson, Julien [1 ]
Lhuillier, Mickael [1 ]
Kolodziej, Allan [2 ]
Olivier, Jean-Luc [2 ]
Karcher, Gilles [1 ,3 ]
Marie, Pierre-Yves [1 ,3 ,4 ]
Maskali, Fatiha [1 ]
机构
[1] Brabois Hosp, Nancyclotep Mol & Expt Imaging Platform, F-54505 Vandoeuvre Les Nancy, France
[2] Univ Lorraine, CHRU Nancy, Dept Biochem & Mol Biol, Nancy, France
[3] Univ Lorraine, CHRU Nancy, Dept Nucl Med, Nancy, France
[4] Univ Lorraine, INSERM, UMR 1116, Nancy, France
关键词
F-18-fluorodeoxyglucose; positron emission tomography; fasting; low-carbohydrate diet; myocarditis; LOW-CARBOHYDRATE-DIET; HIGH-FAT; CARDIAC SARCOIDOSIS; KETONE-BODIES; SUPPRESSION; TOMOGRAPHY; IMPACT;
D O I
10.1007/s12350-018-1404-7
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background Short periods of fasting and/or low-carbohydrate diet have been proven beneficial for decreasing the myocardial uptake of F-18-fluorodeoxyglucose (F-18-FDG) and enhancing the detection of inflammatory heart diseases by F-18-FDG positron emission tomography (PET). This study aimed at determining whether this benefit is increased when a low-carbohydrate ketogenic diet is prolonged up to 7 days. Methods Wistar rats underwent serial F-18-FDG-PET imaging after an 18-hour fasting period and after 2, 4 and 7 days of a ketogenic diet (3% carbohydrate) and they were compared to rats submitted to the same protocol but with normal diet (44% carbohydrate). The F-18-FDG-PET/ketogenic protocol was also applied in rats with immune myocarditis (injection of porcine cardiac myosin). Results The 7-day ketogenic diet was associated with (1) a sustained increase in circulating ketone bodies at an equivalent level to that reached after 18-hour fasting, (2) a gradual decrease in F-18-FDG uptake within normal myocardium reaching a lower level compared to fasting at the 7th day (myocardium-to-blood ratios: 1.68 +/- 1.02 vs 3.25 +/- 1.40, P < .05) and (3) a high F-18-FDG-PET detectability of myocarditis areas. Conclusion One-week extension of a ketogenic diet provides a further decrease in the F-18-FDG uptake of normal myocardium and a high detectability of inflammatory areas.
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收藏
页码:612 / 618
页数:7
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