SARS-CoV-2 receptor ACE2 gene expression in small intestine correlates with age

被引：35

作者：

Vuille-dit-Bille, Raphael N. ^{[1
,2
]}

Liechty, Kenneth W. ^{[3
]}

Verrey, Francois ^{[2
,4
]}

Guglielmetti, Laura C. ^{[5
]}

机构：

[1] Univ Childrens Hosp Basel, Dept Pediat Surg, Spitalstr 33, CH-4056 Basel, Switzerland

[2] Univ Zurich, Inst Physiol, Zurich, Switzerland

[3] Univ Childrens Hosp Colorado, Dept Pediat Surg, Aurora, CO USA

[4] Univ Zurich, Swiss Natl Ctr Competence Res Kidney CH, Zurich, Switzerland

[5] Cantonal Hosp Winterthur, Dept Visceral & Thorac Surg, Winterthur, Switzerland

来源：

AMINO ACIDS | 2020年 / 52卷 / 6-7期

关键词：

ACE2; COVID-19; SARS-CoV-2; Age; CORONAVIRUS;

D O I：

10.1007/s00726-020-02870-z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gastrointestinal symptoms are common in COVID-19 patients, especially in younger patients. Our hypothesis was that intestinal SARS-CoV-2 receptor ACE2 expression depends on patients' age. We examined duodenal biopsies from 43 healthy human adults. ACE2 gene expression was directly correlated with age (Spearman'sr = 0.317,p = 0.039). With each year, duodenal ACE2 expression increased by 0.083 RU. The higher intestinal ACE2 mRNA expression in older patients may impact on their susceptibility to develop intestinal symptoms.

引用

页码：1063 / 1065

页数：3

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