Role of nitric oxide in inflammation

被引:151
作者
Laroux, FS [1 ]
Pavlick, KP [1 ]
Hines, IN [1 ]
Kawachi, S [1 ]
Harada, H [1 ]
Bharwani, S [1 ]
Hoffman, JM [1 ]
Grisham, MB [1 ]
机构
[1] Louisiana State Univ, Hlth Sci Ctr, Dept Cellular & Mol Physiol, Shreveport, LA 71130 USA
来源
ACTA PHYSIOLOGICA SCANDINAVICA | 2001年 / 173卷 / 01期
关键词
ischaemia; liver; NF-kappa B; nitric oxide;
D O I
10.1046/j.1365-201X.2001.00891.x
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
A number of laboratories have sought to elucidate the role of nitric oxide (NO) in both acute and chronic inflammatory diseases. It is now well appreciated that NO can influence many aspects of the inflammatory cascade ranging from its own expression to recruitment of leucocytes to the effected tissue. With the advent of mice selectively deficient in the various isoforms of nitric oxide synthase (NOS), the role that NO may play in various disease states can now be examined in vivo. One such syndrome that has gained much attention in recent years is ischaemia and reperfusion-induced tissue injury. Ishaemia-reperfusion (I/R) injury is an important clinical consideration in situations such as transplantation, trauma, liver or bowel resection and haemorrhagic shock. A hallmark of I/R is the production of reactive oxygen species (ROS) during the reperfusion phase and it is thought that the production of ROS mediate much of the post-ischaemic tissue injury. This review will examine the current state of knowledge regarding the regulatory mechanisms by which NO can influence various aspects of the inflammatory cascade as well as its role in a model of I/R injury in vivo.
引用
收藏
页码:113 / 118
页数:6
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