Clozapine in treatment-resistant schizophrenia: a patient's journey

被引：1

作者：

Korsavva, Sofia ^{[1
]}

Dhadesugur, Seshadri ^{[1
]}

机构：

[1] Locked Psychiat Rehabil High Dependency Unit, Cygnet Hlth Care, Wolverhampton, W Midlands, England

来源：

PROGRESS IN NEUROLOGY AND PSYCHIATRY | 2019年 / 23卷 / 01期

关键词：

OBSESSIVE-COMPULSIVE SYMPTOMS; QUETIAPINE;

D O I：

10.1002/pnp.523

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Treatment-resistant schizophrenia can be very difficult to manage and here the authors discuss the treatment challenges in such a patient who has a dual diagnosis of polysubstance abuse. The patient responded to the unusual combination of clozapine, sertraline, quetiapine, valproate semisodium and clonazepam but there were difficulties with the clozapine titration and augmentation. The clinical management lessons are discussed.

引用

收藏

页码：8 / 10

页数：3

相关论文

共 14 条

[1]

[Anonymous], ROSENBERGS MOL GENET

[2]

AstraZeneca UK Ltd, SEROQUEL XL PROLONGE

[3] Abrupt Improvement in Obsessive-Compulsive Symptoms Upon Discontinuation of Clozapine [J].

Dykema, Lindsay-Rose .

JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 2018, 38 (01) :88-89

[4] Comparison of clozapine-amisulpride and clozapine-quetiapine combinations for patients with schizophrenia who are partially responsive to clozapine:: A single-blind randomized study [J].

Genc, Yasin ;

Taner, Ender ;

Candansayar, Selcuk .

ADVANCES IN THERAPY, 2007, 24 (01) :1-13

[5] Symptom structure of antipsychotic-induced obsessive compulsive symptoms in schizophrenia patients [J].

Kim, Joo Hyun ;

Ryu, Seunghyong ;

Nam, Hee Jung ;

Lim, Meerae ;

Baek, Ji Hyun ;

Joo, Yeon Ho ;

Kwon, Jun Soo ;

Ha, Tae Hyon ;

Hong, Kyung Sue .

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2012, 39 (01) :75-79

[6] Antipsychotic-induced sensitization and tolerance: Behavioral characteristics, developmental impacts, and neurobiological mechanisms [J].

Li, Ming .

JOURNAL OF PSYCHOPHARMACOLOGY, 2016, 30 (08) :749-770

[7] Obsessive-compulsive symptoms induced by atypical antipsychotics. A review of the reported cases [J].

Lykouras, L ;

Alevizos, B ;

Michalopoulou, P ;

Rabavilas, A .

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2003, 27 (03) :333-346

[8] Augmentation with antidepressants in schizophrenia treatment: benefit or risk [J].

Mao, Ye-Meng ;

Zhang, Ming-Dao .

NEUROPSYCHIATRIC DISEASE AND TREATMENT, 2015, 11 :701-713

[9] Physical health monitoring of patients with schizophrenia [J].

Marder, SR ;

Essock, SM ;

Miller, AL ;

Buchanan, RW ;

Casey, DE ;

Davis, JM ;

Kane, JM ;

Lieberman, JA ;

Schooler, NR ;

Covell, N ;

Stroup, S ;

Weissman, EM ;

Wirshing, DA ;

Hall, CS ;

Pogach, L ;

Pi-Sunyer, X ;

Bigger, JT ;

Friedman, A ;

Kleinberg, D ;

Yevich, SJ ;

Davis, B ;

Shon, S .

AMERICAN JOURNAL OF PSYCHIATRY, 2004, 161 (08) :1334-1349

[10] GABA and glutamate in schizophrenia: A 7 T 1H-MRS study [J].

Marsman, Anouk ;

Mandl, Rene C. W. ;

Klomp, Dennis W. J. ;

Bohlken, Marcm. ;

Boer, Vincent O. ;

Andreychenko, Anna ;

Cahn, Wiepke ;

Kahn, Rene S. ;

Luijten, Peter R. ;

Pol, Hilleke E. Hulshoff .

NEUROIMAGE-CLINICAL, 2014, 6 :398-407