Endocytosis by Numb breaks Notch symmetry at cytokinesis

被引：101

作者：

Couturier, Lydie ^{[1
,2
]}

Vodovar, Nicolas ^{[1
,2
]}

Schweisguth, Francois ^{[1
,2
]}

机构：

[1] Inst Pasteur, Dept Dev Biol, F-75015 Paris, France

[2] CNRS, URA2578, F-75015 Paris, France

来源：

NATURE CELL BIOLOGY | 2012年 / 14卷 / 02期

关键词：

ASYMMETRIC CELL-DIVISION; LETHAL-GIANT-LARVAE; MEMBRANE LOCALIZATION; ALPHA-ADAPTIN; DROSOPHILA; SANPODO; PROTEIN; DELTA; ACTIVATION; FATES;

D O I：

10.1038/ncb2419

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cell-fate diversity can be generated by the unequal segregation of the Notch regulator Numb at mitosis in both vertebrates and invertebrates. Whereas the mechanisms underlying unequal inheritance of Numb are understood, how Numb antagonizes Notch has remained unsolved. Live imaging of Notch in sensory organ precursor cells revealed that nuclear Notch is detected at cytokinesis in the daughter cell that does not inherit Numb. Numb and Sanpodo act together to regulate Notch trafficking and establish directional Notch signalling at cytokinesis. We propose that unequal segregation of Numb results in increased endocytosis in one daughter cell, hence asymmetry of Notch at the cytokinetic furrow, directional signalling and binary fate choice.

引用

页码：131 / 139

页数：9

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