Fulminant Epstein-Barr virus-associated hemophagocytic syndrome in a renal transplant patient and review of the literature

被引：7

作者：

Romiopoulos, I. ^{[1
]}

Pyrpasopoulou, A. ^{[1
]}

Onoufriadis, I. ^{[2
]}

Massa, E. ^{[3
]}

Mouloudi, E. ^{[3
]}

Kydona, C. ^{[3
]}

Giasnetsova, T. ^{[3
]}

Gerogianni, N. ^{[3
]}

Myserlis, G. ^{[4
]}

Solonaki, F. ^{[4
]}

Nikodimopoulou, M. ^{[4
]}

Mandala, E. ^{[2
]}

Antachopoulos, C. ^{[1
,5
]}

Roilides, E. ^{[1
,5
]}

机构：

[1] Aristotle Univ Thessaloniki, Sch Hlth Sci, Hippokrat Hosp, Infect Dis Unit,Fac Med, Thessaloniki, Greece

[2] Aristotle Univ Thessaloniki, Sch Hlth Sci, Hippokrat Hosp, Fac Med,Internal Med Dept 4, Thessaloniki, Greece

[3] Hippokrateion Hosp, Intens Care Unit, Thessaloniki, Greece

[4] Aristotle Univ Thessaloniki, Sch Hlth Sci, Hippokrat Hosp, Transplantat Dept,Fac Med, Thessaloniki, Greece

[5] Aristotle Univ Thessaloniki, Hippokrat Gen Hosp, Dept Pediat 3, Thessaloniki, Greece

来源：

TRANSPLANT INFECTIOUS DISEASE | 2016年 / 18卷 / 05期

关键词：

EBV; hemophagocytic syndrome; pancytopenia; renal transplantation; LYMPHOHISTIOCYTOSIS; EBV; RECIPIENTS; INFECTIONS;

D O I：

10.1111/tid.12586

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We describe a rare fulminant case of Epstein-Barr virus-associated hemophagocytic syndrome (HPS) in a 37-year-old female renal transplant patient, indistinguishable from severe sepsis clinically and in the laboratory. HPS involves rapidly escalating immune system activation, resulting in a cytokine cascade, which can, especially in immunocompromised patients, lead to multi-organ failure, and even death. Thirty-two Herpesviridae-associated HPS cases in renal transplant patients have been reported and are reviewed. Overall mortality is 47% (15/32 cases).

引用

页码：795 / 800

页数：6

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