Pro198Leu missense polymorphism of the glutathione peroxidase 1 gene might be a common genetic predisposition of distal symmetric polyneuropathy and macrovascular disease in Japanese type 2 diabetic patients

被引：7

作者：

Matsuno, Shohei ^{[1
]}

Sasaki, Hideyuki ^{[1
]}

Yamasaki, Hiroshi ^{[1
]}

Yamaoka, Hiroyuki ^{[1
]}

Ogawa, Kenichi ^{[1
]}

Nakatani, Muneki ^{[1
]}

Hamanishi, Tohru ^{[1
]}

Doi, Asako ^{[1
]}

Nakano, Yoshio ^{[1
]}

Wakasaki, Hisao ^{[1
]}

Furuta, Hiroto ^{[1
]}

Nishi, Masahiro ^{[1
]}

Akamizu, Takashi ^{[1
]}

Nanjo, Kishio ^{[1
]}

机构：

[1] Wakayama Med Univ, Dept Med 1, Wakayama, Japan

来源：

JOURNAL OF DIABETES INVESTIGATION | 2011年 / 2卷 / 06期

关键词：

Glutathione peroxidase 1 gene; Diabetic distal symmetric polyneuropathy; Macrovascular disease; DIAGNOSTIC-CRITERIA; METABOLIC SYNDROME; GLUCOSE-TOLERANCE; NEUROPATHY; RISK; COMPLICATIONS; ASSOCIATION; STATEMENT;

D O I：

10.1111/j.2040-1124.2011.00127.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims/Introduction: We have previously reported that the Pro198Leu missense polymorphism in the glutathione peroxidase 1 (GPx-1) gene was associated with frequent macrovascular disease (MVD). Our goal was to examine whether the GPx-1 genotype is associated with diabetic neuropathy.

引用

收藏

页码：474 / 482

页数：9

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