Intravenous immunoglobulin - Indications and mechanisms in cardiovascular diseases

被引：63

作者：

Udi, Nussinovitch ^{[1
,2
]}

Yehuda, Shoenfeld ^{[1
,2
,3
]}

机构：

[1] Chaim Sheba Med Ctr, Dept Med B, WM Keck Autoimmune Dis Ctr, IL-52621 Tel Hashomer, Israel

[2] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel

[3] Tel Aviv Univ, Laura Schwarz Kipp Chair Res Autoimmune Dis, IL-69978 Tel Aviv, Israel

来源：

AUTOIMMUNITY REVIEWS | 2008年 / 7卷 / 06期

关键词：

intravenous immunoglobulins (IVIG); heart failure; dilated cardiomyopathy; autoimmunity; tumor necrosis factor alpha (TNF alpha);

D O I：

10.1016/j.autrev.2008.04.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Intravenous immutioglobulin (IVIG) is efficient in various immune mediated conditions. Various cardiovascular diseases are mediated by inflammatory processes and autoimmune mechanisms. Therefore, it seems conceivable to employ IVIG as an immunomodulating therapy in such indications. In this paper we review the possible anti-inflammatory effects of WIG transfusion, and discuss the possible clinical implications in cardiology. Besides the established use of IVIG in Kawasaki disease, IVIG may be beneficial in some cases of heart failure, dilated cardiomyopathy, myocarditis, pericardial diseases, neonatal lupus, in the prevention of cardiac rejection following transplantation, and in modulating atherosclerosis. IVIG has been proven to be ineffective in rheumatic fever. Although uncommon, complications may arise including myocardial infarction, renal failure and hyperviscosity. IVIG should be administered based on accepted modes of transfusion. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：445 / 452

页数：8

共 40 条

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