Interactions between the neuropeptide Y system and the hypothalamic-pituitary-adrenal axis

被引：74
|
作者：
Krysiak, R [1 ]
Obuchowicz, E [1 ]
Herman, ZS [1 ]
机构：
[1] Silesian Univ, Sch Med, Dept Clin Pharmacol, PL-40752 Katowice, Poland
来源：
EUROPEAN JOURNAL OF ENDOCRINOLOGY | 1999年 / 140卷 / 02期
关键词：
D O I：
10.1530/eje.0.1400130
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The aim of this paper is to review the present knowledge of interactions between the neuropeptide Y (NPY) system and the hypothalamic-pituitary-adrenal (HPA) axis. On the basis of in vitro and in vivo studies of various animal species, we review the effects of NPY on all levels of HPA axis activity. We also describe the effects of glucocorticosteroids on the NPY system in the hypothalamus, including interactions between glucocorticosteroids and insulin. On the basis of available literature, we discuss the role of these interactions in the control of food intake and in the pathogenesis of obesity.
引用
收藏
页码：130 / 136
页数：7
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