Low prevalence of Human Papillomavirus in oral cavity carcinomas

被引：71

作者：

Machado, Jerry ^{[1
,2
]}

Reis, Patricia P. ^{[2
]}

Zhang, Tong ^{[2
]}

Simpson, Colleen ^{[3
]}

Xu, Wei ^{[4
]}

Perez-Ordonez, Bayardo ^{[5
]}

Goldstein, David P. ^{[3
]}

Brown, Dale H. ^{[3
]}

Gilbert, Ralph W. ^{[3
]}

Gullane, Patrick J. ^{[3
]}

Irish, Jonathan C. ^{[3
]}

Kamel-Reid, Suzanne ^{[1
,2
,6
,7
]}

机构：

[1] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada

[2] Princess Margaret Hosp, Ontario Canc Inst, Div Appl Mol Oncol, Toronto, ON M4X 1K9, Canada

[3] Princess Margaret Hosp, Ontario Canc Inst, Dept Otolaryngol Surg Oncol, Toronto, ON M4X 1K9, Canada

[4] Princess Margaret Hosp, Dept Biostat, Univ Hlth Network, Toronto, ON M4X 1K9, Canada

[5] Toronto Gen Hosp, Dept Pathol, Univ Hlth Network, Toronto, ON, Canada

[6] Univ Toronto, Inst Med Sci, Toronto, ON M5S 1A1, Canada

[7] Univ Toronto, Dept Med Biophys, Toronto, ON, Canada

来源：

HEAD & NECK ONCOLOGY | 2010年 / 2卷

关键词：

SQUAMOUS-CELL CARCINOMAS; NECK-CANCER; RISK-FACTOR; HEAD; DNA; PROFILES; TYPE-16; BASE;

D O I：

10.1186/1758-3284-2-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Increasing evidence shows that Human Papillomavirus (HPV) is preferentially associated with some head and neck squamous cell carcinomas (HNSCCs), with variable infection rates reported. Methods: We assessed HPV involvement in HNSCC using the Roche Linear Array HPV Genotyping Test, which can detect 37 different HPV types. We examined the prevalence of HPV infection in 92 HNSCCs (oropharynx, oral cavity, and other HNSCC sites). Results: HPV was frequently detected in oropharyngeal cancers (OPCs) (16/22, 73%), but was uncommon in oral cavity cancers (2/53, 4%), and in other HNSCC subsites (1/17, 6%). HPV positive tumors were associated with patients that were 40-60 years old (p = 0.02), and node positive (p = < 0.0001). HPV 16 was the most prevalent type, but other types detected included 6, 18, 33, 35, 45, and 52/58. Conclusion: Our results show that in contrast to oropharyngeal cancers, oral cancers and other HNSCCs infrequently harbor HPV.

引用

页数：6

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