New insights into viral structure and virus-cell interactions through proteomics

被引：9
作者：
Bernhard, OK
Diefenbach, RJ
Cunningham, AL
机构：
[1] Westmead Hosp, Westmead Millennium Inst, Ctr Virus Res, Westmead, NSW 2145, Australia
[2] Univ Sydney, Westmead, NSW 2145, Australia
[3] Natl Ctr HIV & Hepatitis Virol Res, Westmead, NSW 2145, Australia
来源：
EXPERT REVIEW OF PROTEOMICS | 2005年 / 2卷 / 04期
关键词：
crosslinking; herpes simplex virus; HIV; protein complexes; virus entry; virus receptor; virus transport and assembly;
D O I：
10.1586/14789450.2.4.577
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Although genomics techniques such as DNA microarrays have been widely used in virology, much more limited use has been made of proteomics. Although difficult, proteomics can greatly contribute to an understanding of virus-cell interactions, including the ternary structure of viral receptors at the cell surface, post-translational modifications and isoforms of critical viral and cellular proteins and even to the structure of viruses. Proteomics techniques also offer the potential for discovering markers for diagnostic and prognostic tests of viral infections in vivo. This review describes the use of several proteomic approaches for the analysis of HIV-cellular receptor interactions, the molecular mechanisms of transport of herpes simplex virus within neurons, and the structure of the tegument of herpes simplex virus.
引用
收藏
页码：577 / 588
页数：12
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