Oxidative Stress Index Levels in Asian Adolescents with Exogenous-Constitutional Obesity

The aim of this research was to evaluate the integral oxidative stress index (OSI) level in Asian girls and boys with exogenous-constitutional obesity. Methods and Results: A total of 170 Asian adolescents aged 12-18 years were examined: 26 girls and 28 boys with constitutional obesity (main group, MG); 59 girls and 57 boys - healthy adolescents (control group, CG). The levels of lipid peroxidation (LPO) products and antioxidant defense (AOD) parameters were detected using spectrophotometric and fluorometric methods. The level of LPO products and AOD components in the studied groups were assessed to calculate the integral OSI. Significant increases in the levels of primary LPO products (conjugated dienes by 2.18 times) and secondary LPO products (ketodienes and conjugated trienes by 2.48 times) in the obese Asian girls, compared with the control values, were observed. We found a significant decrease in the parameters of the AOD system in the obese Asian girls, compared with the control values: a-tocopherol (by 1.41 times; P=0.0262), retinol (by 1.12 times; P=0.0306), and SOD activity (by 1.28 times; P=0.0004). In the obese Asian boys, increased values of LPO components were found, compared to controls: conjugated dienes (by 2.13 times; P<0.0001), ketodienes and conjugated trienes (by 3.4 times; P<0.0001), final thiobarbituric acid reactants of LPO (by 1.24 times; P=0.0358). They showed a statistically significant decrease in the level of alpha-tocopherol (by 1.49 times; P=0.01), compared with the control values. According to the obtained data, OSI in the group of Asian girls with obesity was 15.68 units, in the group of Asian boys with obesity - 22.89 units. The OSI in the group of Asian boys was significantly higher (by 1.46 times; P=0.0492) than in the obese girls. Conclusion: Certain OSI levels are consistent with the presence of antioxidant insufficiency in exogenous-constitutional obesity and allow us to specify and evaluate the ethnic aspect of the severity of the pathological process more reliably.