Relating retinal blood flow and vessel morphology in sickle cell retinopathy

被引:20
作者
Cano, Jennifer [1 ]
Farzad, Shayan [1 ]
Khansari, Maziyar M. [1 ]
Tan, Ou [2 ]
Huang, David [2 ]
Lim, Jennifer, I [3 ]
Shahidi, Mahnaz [1 ]
机构
[1] Univ Southern Calif, Ophthalmol, Los Angeles, CA 90007 USA
[2] Oregon Hlth & Sci Univ, Casey Eye Inst, Portland, OR 97201 USA
[3] Univ Illinois, Ophthalmol & Visual Sci, Chicago, IL USA
关键词
COHERENCE TOMOGRAPHY ANGIOGRAPHY; OCULAR MANIFESTATIONS; DISEASE; CLASSIFICATION; TORTUOSITY; DIAMETER; INCREASE; FEATURES;
D O I
10.1038/s41433-019-0604-y
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Purpose The purpose of the current study was to determine associations between retinal blood flow and vessel morphology metrics in sickle cell retinopathy (SCR) and healthy normal control (NC) subjects. Methods Optical coherence tomography angiography (OCTA) and Doppler OCT imaging were performed in 12 SCR (15 eyes) and 19 NC (26 eyes) subjects. Vessel tortuosity was measured using a dedicated image analysis algorithm applied to OCTA images. Vessel density and spacing between vessels were determined from OCTA images by a fractal dimension analysis method. Retinal blood flow was quantified using a phase-resolved technique applied to en face Doppler OCT images. Results There was a significant association between increased retinal blood flow and increased vessel tortuosity (P = 0.03). Furthermore, increased retinal blood flow was associated with increased vessel density (P = 0.03) and decreased spacing between small vessels (P = 0.01). There was no significant association between retinal blood flow and spacing between large vessels (P = 0.11). Vessel tortuosity and blood flow were increased, whereas spacing between small vessels was decreased in SCR compared to NC group (P <= 0.03). There were no significant differences in vessel density or spacing between large vessels between the SCR and NC groups (P >= 0.31). Conclusions Associations between retinal hemodynamics and vessel morphology were reported, providing better understanding of retinal pathophysiology and insight into potential quantitative biomarkers to evaluate SCR.
引用
收藏
页码:886 / 891
页数:6
相关论文
共 35 条
[1]   Computer-aided classification of sickle cell retinopathy using quantitative features in optical coherence tomography angiography [J].
Alam, Minhaj ;
Thapa, Damber ;
Lim, Jennifer I. ;
Cao, Dingcai ;
Yao, Xincheng .
BIOMEDICAL OPTICS EXPRESS, 2017, 8 (09) :4206-4216
[2]   Quantitative characteristics of sickle cell retinopathy in optical coherence tomography angiography [J].
Alam, Minhaj ;
Thapa, Damber ;
Lim, Jennifer I. ;
Cao, Dingcai ;
Yao, Xincheng .
BIOMEDICAL OPTICS EXPRESS, 2017, 8 (03) :1741-1753
[3]   Linking Retinal Microvasculature Features With Severity of Diabetic Retinopathy Using Optical Coherence Tomography Angiography [J].
Bhanushali, Devanshi ;
Anegondi, Neha ;
Gadde, Santosh G. K. ;
Srinivasan, Priya ;
Chidambara, Lavanya ;
Yadav, Naresh Kumar ;
Roy, Abhijit Sinha .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2016, 57 (09) :OCT519-OCT525
[4]   Retinal microcirculation imaging in sickle cell disease patients [J].
Birkhoff, W. ;
de Vries, J. ;
Dent, G. ;
Verma, A. ;
Kerkhoffs, J. L. ;
van Meurs, A. H. F. ;
de Kam, M. ;
Moerland, M. ;
Burggraaf, J. .
MICROVASCULAR RESEARCH, 2018, 116 :1-5
[5]   Sickle cell retinopathy: diagnosis and treatment [J].
Brizzi Chizzotti Bonanomi, Maria Teresa ;
Lavezzo, Marcelo Mendes .
ARQUIVOS BRASILEIROS DE OFTALMOLOGIA, 2013, 76 (05) :320-327
[6]   OCULAR FINDINGS IN ELDERLY CASES OF HOMOZYGOUS SICKLE-CELL DISEASE IN JAMAICA [J].
CONDON, PI ;
SERJEANT, GR .
BRITISH JOURNAL OF OPHTHALMOLOGY, 1976, 60 (05) :361-364
[7]   Plus Disease [J].
Davitt, Bradley V. ;
Wallace, David K. .
SURVEY OF OPHTHALMOLOGY, 2009, 54 (06) :663-670
[8]  
DEJONG PE, 1984, CLIN NEPHROL, V22, P212
[9]   Ocular manifestations of sickle cell disease [J].
Fadugbagbe, A. O. ;
Gurgel, R. Q. ;
Mendonca, C. Q. ;
Cipolotti, R. ;
dos Santos, A. M. ;
Cuevas, L. E. .
ANNALS OF TROPICAL PAEDIATRICS, 2010, 30 (01) :19-26
[10]   Quantification of Vessel Density in Retinal Optical Coherence Tomography Angiography Images Using Local Fractal Dimension [J].
Gadde, Santosh G. K. ;
Anegondi, Neha ;
Bhanushali, Devanshi ;
Chidambara, Lavanya ;
Yadav, Naresh Kumar ;
Khurana, Aruj ;
Roy, Abhijit Sinha .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2016, 57 (01) :246-252