Maklamicin, an Antibacterial Polyketide from an Endophytic Micromonospora sp.

被引：100

作者：

Igarashi, Yasuhiro ^{[1
]}

Ogura, Hiromu ^{[1
]}

Furihata, Kazuo ^{[2
]}

Oku, Naoya ^{[1
]}

Indananda, Chantra ^{[3
]}

Thamchaipenet, Arinthip ^{[3
]}

机构：

[1] Toyama Prefectural Univ, Biotechnol Res Ctr, Toyama 9390398, Japan

[2] Univ Tokyo, Grad Sch Agr & Life Sci, Dept Appl Biol Chem, Bunkyo Ku, Tokyo 1138657, Japan

[3] Kasetsart Univ, Fac Sci, Dept Genet, Bangkok 10900, Thailand

来源：

JOURNAL OF NATURAL PRODUCTS | 2011年 / 74卷 / 04期

关键词：

J-RESOLVED HMBC; ROOT-NODULES; SP NOV; POLYCYCLIC POLYKETIDE; CONFIGURATION; TETROCARCIN;

D O I：

10.1021/np100727h

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new spirotetronate-class polyketide, maklamicin (1), was isolated from the culture extract. of an endophytic actinomycete of the genus Micromonospora. The structure and relative configuration of were elucidated by interpretation of NMR and other spectroscopic data, and the absolute configuration was determined using the Modified Mosher method: Maklamicin (1) showed strong to modest antimicrobial activity against Gram-positive bacteria.

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页码：670 / 674

页数：5

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