Multiple-locus variable number tandem repeats analysis for genetic fingerprinting of pathogenic bacteria

被引:241
作者
Lindstedt, BA [1 ]
机构
[1] Norwegian Inst Publ Hlth, Div Infect Dis Control, N-0403 Oslo, Norway
关键词
DNA fingerprinting; multiple-locus variable-number tandem repeats analysis; pathogenic bacteria; review;
D O I
10.1002/elps.200500096
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
DNA fingerprinting has attracted considerable interest as means for identifying, tracing and preventing the dissemination of infectious agents. Various methods have been developed for typing of pathogenic bacteria, which differ in discriminative power, reproducibility and ease of interpretation. During recent years a typing method, which uses the information provided by whole genome sequencing of bacterial species, has gained increased attention. Short sequence repeat (SSR) motifs are known to undergo frequent variation in the number of repeated units through cellular mechanisms most commonly active during chromosome replication. A class of SSRs, named variable number of tandem repeats (VNTRs), has proven to be a suitable target for assessing genetic polymorphisms within bacterial species. Thins review attempts to give an overview of bacterial agents where VNTR-based typing, or multiple-locus variant-repeat analysis (MLVA) has been developed for typing purposes, together with addressing advantages and drawbacks associated with the use of tandem repeated DNA motifs as targets for bacterial typing and identification.
引用
收藏
页码:2567 / 2582
页数:16
相关论文
共 154 条
  • [81] Identifying sources of human exposure to plague
    Lowell, JL
    Wagner, DM
    Atshabar, B
    Antolin, MF
    Vogler, AJ
    Keim, P
    Chu, MC
    Gage, KL
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 2005, 43 (02) : 650 - 656
  • [82] Identification of variable-number tandem-repeat loci in Leptospira interrogans sensu stricto
    Majed, Z
    Bellenger, E
    Postic, D
    Pourcel, C
    Baranton, G
    Picardeau, M
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 2005, 43 (02) : 539 - 545
  • [83] Experimentally revised repertoire of putative contingency loci in Neisseria meningitidis strain MC58:: evidence for a novel mechanism of phase variation
    Martin, P
    van de Ven, T
    Mouchel, N
    Jeffries, AC
    Hood, DW
    Moxon, ER
    [J]. MOLECULAR MICROBIOLOGY, 2003, 50 (01) : 245 - 257
  • [84] Matsuoka M, 2000, INT J LEPROSY, V68, P121
  • [85] DNA MARKERS IN FORENSIC MEDICINE
    MAYR, WR
    [J]. TRANSFUSION CLINIQUE ET BIOLOGIQUE, 1995, 2 (04) : 325 - 328
  • [86] Complete genome sequence of Salmonella enterica serovar typhimurium LT2
    McClelland, M
    Sanderson, KE
    Spieth, J
    Clifton, SW
    Latreille, P
    Courtney, L
    Porwollik, S
    Ali, J
    Dante, M
    Du, FY
    Hou, SF
    Layman, D
    Leonard, S
    Nguyen, C
    Scott, K
    Holmes, A
    Grewal, N
    Mulvaney, E
    Ryan, E
    Sun, H
    Florea, L
    Miller, W
    Stoneking, T
    Nhan, M
    Waterston, R
    Wilson, RK
    [J]. NATURE, 2001, 413 (6858) : 852 - 856
  • [87] Natural population dynamics and expansion of pathogenic clones of Staphylococcus aureus
    Melles, DC
    Gorkink, RFJ
    Boelens, HAM
    Snijders, SV
    Peeters, JK
    Moorhouse, MJ
    van der Spek, PJ
    van Leeuwen, WB
    Simons, G
    Verbrugh, HA
    van Belkum, A
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2004, 114 (12) : 1732 - 1740
  • [88] The zoonotic importance of Mycobacterium bovis
    Moda, G
    Daborn, CJ
    Grange, JM
    Cosivi, O
    [J]. TUBERCLE AND LUNG DISEASE, 1996, 77 (02): : 103 - 108
  • [89] MORRISON AJ, 1984, REV INFECT DIS, V6, pS627
  • [90] ADAPTIVE EVOLUTION OF HIGHLY MUTABLE LOCI IN PATHOGENIC BACTERIA
    MOXON, ER
    RAINEY, PB
    NOWAK, MA
    LENSKI, RE
    [J]. CURRENT BIOLOGY, 1994, 4 (01) : 24 - 33