Unilateral lesion detected on preoperative multiparametric magnetic resonance imaging and MRI/US fusion-guided prostate biopsy is not an appropriate indication for focal therapy in prostate cancer

被引：8

作者：

Zhou, Zhien ^{[1
]}

Zhou, Yi ^{[1
]}

Yan, Weigang ^{[1
]}

Sun, Hao ^{[2
]}

Li, Qianyue ^{[3
]}

Li, Hanzhong ^{[1
]}

Ji, Zhigang ^{[1
]}

机构：

[1] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Peking Union Med Coll, Dept Urol, Beijing, Peoples R China

[2] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Peking Union Med Coll, Dept Radiol, Beijing, Peoples R China

[3] Gen Hosp Xinjiang Prod & Construct Corps, Dept Urol, Urumqi, Xinjiang, Peoples R China

来源：

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS | 2021年 / 39卷 / 10期

关键词：

Magnetic resonance imaging /ultrasound (MRI/US) fusion-targeted biopsy; Imaging guided biopsy; Focal therapy; prostate cancer; PRIOR NEGATIVE BIOPSY; ULTRASOUND FUSION; TARGETED BIOPSY;

D O I：

10.1016/j.urolonc.2021.04.021

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose: This study aimed to investigate if preoperative assessments of multiparametric magnetic resonance imaging (mpMRI) and Magnetic resonance imaging /ultrasound (MRI/US) fusion-guided prostate biopsy could be used to guide focal therapy for prostate cancer. Materials and Methods: A total of 101 prostate cancer patients undergoing radical prostatectomy were included. Preoperative findings included mpMRI and MRI/US fusion-guided prostate biopsy, while postoperative whole mount pathology was based on surgical specimen. Results: Of the 101 patients preoperatively diagnosed with a unilateral tumor, postoperative whole mount pathology showed 73.27% were bilateral tumors, and 71.62% of bilateral lesions were clinically significant. Comparison between preoperative and postoperative findings, the correct rate of preoperative mpMRI on the lesion side (left or right) was only 20.79%. As for the Gleason score, the correct rate of preoperative MRI/US fusion-guided prostate pathology was 67.33%. Judging from postoperative whole mount pathology, 47.52% of patients had a unilateral clinically significant tumor, which is an indication for focal therapy. Conclusion: Preoperative examinations of mpMRI and MRI/US fusion-guided prostate biopsy cannot be used to guide focal therapy for prostate cancer. (C) 2021 Published by Elsevier Inc.

引用

页码：730.e17 / 730.e22

页数：6

共 23 条

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