Practical and Novel One-Pot Protocol for the Synthesis of Highly Functionalized Pyridinols and Pyrido[1,2-a]-Fused 1,3-Diazaheterocycles

被引：18

作者：

Alizadeh, Abdolali ^{[1
]}

Rezvanian, Atieh ^{[1
]}

机构：

[1] Tarbiat Modares Univ, Dept Chem, Tehran 18716, Iran

来源：

SYNLETT | 2011年 / 08期

关键词：

pyridinol; pyrido[1,2-a]-fused 1,3-diazaheterocycle; Michael addition reaction; 1; n-diamine; nitro ketene dithioacetal; l-bis(methylthio)-2-nitroethene; dibenzylideneacetone; HETEROCYCLIC KETENE AMINALS; DIELS-ALDER REACTIONS; CYCLOCONDENSATION REACTIONS; FUSED DIAZAHETEROCYCLES; SUBSTITUTED PYRIDINES; ETHYL BROMOACETATE; CARBONYL COMPOUNDS; FACILE SYNTHESIS; ALKYLATION; CHLORIDE;

D O I：

10.1055/s-0030-1259942

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel and efficient protocol for the generation of substituted pyridinols and pyrido[1,2-a]-fused 1,3-diazaheterocycles from primary amine or 1, n-diamine, nitro ketene dithioacetal [1, l-bis(methylthio)-2-nitroethene] and dibenzylideneacetone as starting materials in a one-pot process combining a Michael addition reaction and nucleophilic addition under mild condition in high yield has been developed.

引用

页码：1105 / 1108

页数：4

共 58 条

[1] A Novel and One-Pot Multicomponent Approach to the Synthesis of Dihyroindeno[1,2-b]pyrroles and Indeno[2′,1′:4,5]pyrrolo[1,2-a]-Fused 1,3-Diazaheterocycles [J].