Effect of subchronic lithium treatment on citalopram-induced increases in extracellular concentrations of serotonin in the medial prefrontal cortex

被引：26

作者：

Muraki, I ^{[1
]}

Inoue, T ^{[1
]}

Hashimoto, S ^{[1
]}

Izumi, T ^{[1
]}

Ito, K ^{[1
]}

Koyama, T ^{[1
]}

机构：

[1] Hokkaido Univ, Sch Med, Dept Psychiat, Kita Ku, Sapporo, Hokkaido 0608638, Japan

来源：

JOURNAL OF NEUROCHEMISTRY | 2001年 / 76卷 / 02期

关键词：

citalopram; in vivo microdialysis; lithium; serotonin; SSRI;

D O I：

10.1046/j.1471-4159.2001.00091.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We investigated the effect of citalopram [a selective serotonin (5-HT) reuptake inhibitor; SSRI] and MKC-242 (a selective 5-HT1A agonist), following treatment with subchronic lithium (p.o., 1 week) on extracellular 5-HT concentrations in the medial prefrontal cortex (mPFC). Acute treatment with citalopram (3 and 30 mg/kg) led to significant increases in extracellular 5-HT concentrations. The subchronic lithium group showed significantly higher basal levels of extracellular 5-HT than normal diet controls. Acute citalopram (3 and 30 mg/kg) treatment together with subchronic lithium treatment showed significant increases in the extracellular 5-HT concentrations, compared with citalopram treatment alone. Acute MKC-242 (1 mg/kg) treatment showed significant decreases in extracellular 5-HT concentrations, in both the normal diet and lithium diet groups to the same extent. The addition of lithium did not change the effect of the 5-HT1A agonist on extracellular 5-HT concentrations. This study suggests that lithium augmentation of the antidepressant effect of SSRI is mediated by the additional increases in extracellular 5-HT concentrations following the co-administrations of lithium and SSRI.

引用

页码：490 / 497

页数：8

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