Identification of 400 novel alleles at the HLA-A, -B, -C,-DRB1,-DQB1 loci from China Marrow Donor Program

被引：4

作者：

Chai, X. ^{[1
]}

Zhang, H. ^{[1
]}

Yang, X. ^{[1
]}

Yang, F. ^{[1
]}

Liu, N. ^{[1
]}

机构：

[1] BGI Shenzhen, Bldg 11,3 Beishan Ind Zone, Shenzhen 518083, Peoples R China

来源：

HLA | 2017年 / 90卷 / 03期

关键词：

HLA-A; HLA-B; HLA-C; HLA-DQB1; HLA-DRB1; novel allele;

D O I：

10.1111/tan.13071

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Four hundred novel human leukocyte antigen (HLA) alleles were identified in Chinese individuals: 100 HLA-A alleles, 100 HLA-B alleles, 101 HLA-C alleles, 28 HLA-DRB1 alleles and 71 HLA-DQB1 alleles. Comparing novel alleles with their most homologous allele, we found 72.73% non-synonymous nucleotide substitutions, 21.13% silent mutations, 3.90% nonsense mutations and 3.25% frame-shift mutation. 352 (88%) of the 400 novel alleles are single nucleotide substitution variants when compared with their most homologous alleles and other novel alleles differ from their most similar allele by more than 1 nucleotide substitutions, such as 2, 3, 5, 6, 8 and so on. Some of the novel alleles are characterized by long deletions or insertions, for example there is 23 bp deletion in the B*58:31N allele when compared to its most homologous allele B*58:01:01:01.

引用

页码：171 / 173

页数：3