Hyperglycemia induced the Alzheimer's proteins and promoted loss of synaptic proteins in advanced-age female Goto-Kakizaki (GK) rats

被引：16

作者：

Pintana, Hiranya ^{[1
,2
,3
]}

Apaijai, Nattayaporn ^{[1
,3
]}

Kerdphoo, Sasiwan ^{[1
,3
]}

Pratchayasakul, Wasana ^{[1
,2
,3
]}

Sripetchwandee, Jirapas ^{[1
,2
,3
]}

Suntornsaratoon, Panan ^{[4
,5
]}

Charoenphandhu, Narattaphol ^{[4
,5
,6
]}

Chattipakorn, Nipon ^{[1
,2
,3
]}

Chattipakorn, Siriporn C. ^{[1
,3
,7
]}

机构：

[1] Chiang Mai Univ, Fac Med, Cardiac Electophysiol Res & Training Ctr, Neurophysiol Unit, Chiang Mai 50200, Thailand

[2] Chiang Mai Univ, Fac Med, Dept Physiol, Chiang Mai 50200, Thailand

[3] Chiang Mai Univ, Ctr Excellence Cardiac Electophysiol Res, Chiang Mai 50200, Thailand

[4] Mahidol Univ, Ctr Calcium & Bone Res COCAB, Fac Sci, Bangkok 10400, Thailand

[5] Mahidol Univ, Fac Sci, Dept Physiol, Bangkok 10400, Thailand

[6] Mahidol Univ, Inst Mol Biosci, Salaya 73170, Nakhon Pathom, Thailand

[7] Chiang Mai Univ, Fac Dent, Dept Oral Biol & Diagnost Sci, Chiang Mai 50200, Thailand

来源：

NEUROSCIENCE LETTERS | 2017年 / 655卷

关键词：

Goto-Kakizaki (GK) rat; Type 2 diabetes mellitus (T2DM); Advanced-age; Alzheimer's protein; Synaptic proteins; TYPE-2; DIABETES-MELLITUS; MEMORY IMPAIRMENT; ANIMAL-MODEL; DISEASE; MICE; ASSOCIATION; DEMENTIA; ATROPHY;

D O I：

10.1016/j.neulet.2017.06.041

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Although both type 2 diabetes mellitus (T2DM) and aging are related with Alzheimer's disease (AD), the effects of aging on the Alzheimer's proteins and the synaptic markers in T2DM have not been investigated. This study, we hypothesized that T2DM rats with advanced-age, aggravates the reduction of synaptic proteins and an increase in the Alzheimer's protein markers. Goto-Kakizaki rats (GK) were used as a T2DM group and wild-type rats (WT) were used as a control group. Rats in each group were categorized by age into young-adult (7 months) and advanced-age rats (12.5 months). Blood was collected in all rats to determine plasma glucose and insulin levels. The brains were used for determining the level of Alzheimer's and synaptic proteins. Our data demonstrated that GK rats had a decreased body weight and increased blood glucose levels, compared to their age-matched WT. p-Tau was increased in both advanced-age WT and GK, compared to their young-adult rats. Moreover, amyloid-beta (A beta) level was higher in advanced-age GK than their age-matched WT. The synaptic proteins were decreased in advanced-age GK, compared to young-adult GK rats. However, no difference in the level of Alzheimer's proteins and synaptic proteins in the brains of young-adult GK compared to age-matched WT was found. Our data suggested that aging contributes to the pathogenesis of AD and the reduction of synaptic proteins to greater extent in a diabetic than in a healthy condition. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：41 / 45

页数：5

共 36 条

[11] Type 2 diabetes affects hippocampus volume differentially in men and women [J].