A new three-carbon synthon for efficient synthesis of benzannelated and 1-(2-arylethenyl) heterocycles

被引：75
|
作者：
Katritzky, AR [1 ]
Tymoshenko, DO
Monteux, D
Vvedensky, V
Nikonov, G
Cooper, CB
Deshpande, M
机构：
[1] Univ Florida, Dept Chem, Ctr Heterocycl Cpds, Gainesville, FL 32611 USA
[2] Bristol Myers Squibb Co, Pharmaceut Res Inst, Princeton, NJ 08563 USA
[3] Bristol Myers Squibb Co, Pharmaceut Res Inst, Wallingford, CT 06492 USA
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2000年 / 65卷 / 23期
关键词：
D O I：
10.1021/jo000946r
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The novel three-carbon synthon 1-(1H-1,2,3-benzotriazol-1-yl)-3-chloroacetone for the synthesis of benzothiazoles, pyrido[1,2-a]indoles, and styryl-substituted indolizines and imidazo[1,2-a]pyridines is reported. The proposed routes are a general and efficient approach for heterocyclizations followed by benzannelations or attachment of arylethenyl pharmacophores.
引用
收藏
页码：8059 / 8062
页数：4
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