A new three-carbon synthon for efficient synthesis of benzannelated and 1-(2-arylethenyl) heterocycles

被引：75

作者：

Katritzky, AR ^{[1
]}

Tymoshenko, DO

Monteux, D

Vvedensky, V

Nikonov, G

Cooper, CB

Deshpande, M

机构：

[1] Univ Florida, Dept Chem, Ctr Heterocycl Cpds, Gainesville, FL 32611 USA

[2] Bristol Myers Squibb Co, Pharmaceut Res Inst, Princeton, NJ 08563 USA

[3] Bristol Myers Squibb Co, Pharmaceut Res Inst, Wallingford, CT 06492 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2000年 / 65卷 / 23期

关键词：

D O I：

10.1021/jo000946r

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The novel three-carbon synthon 1-(1H-1,2,3-benzotriazol-1-yl)-3-chloroacetone for the synthesis of benzothiazoles, pyrido[1,2-a]indoles, and styryl-substituted indolizines and imidazo[1,2-a]pyridines is reported. The proposed routes are a general and efficient approach for heterocyclizations followed by benzannelations or attachment of arylethenyl pharmacophores.

引用

页码：8059 / 8062

页数：4

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