An integrated current measurement system for nanopore analysis

被引：21
作者：
Gao, Rui [1 ]
Ying, Yi-Lun [1 ]
Yan, Bing-Yong [2 ]
Long, Yi-Tao [1 ]
机构：
[1] E China Univ Sci & Technol, Dept Chem, Key Lab Adv Mat, Shanghai 200237, Peoples R China
[2] E China Univ Sci & Technol, Sch Informat Sci & Engn, Shanghai 200237, Peoples R China
来源：
CHINESE SCIENCE BULLETIN | 2014年 / 59卷 / 35期
基金：
中国国家自然科学基金;
关键词：
Nanopore analysis; Current amplification; A/D convertor; Ultralow current detection; ALPHA-HEMOLYSIN; SINGLE; TRANSLOCATION; DNA; RECORDINGS; NOISE;
D O I：
10.1007/s11434-014-0656-0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Nanopore-based techniques have attracted increasing attention as a unique tool for single-molecule analysis. To accurately detect individual motions of each single molecule, nanopore techniques are used to develop an ultrasensitive current measurement system. This work proposes an integrated current measurement system containing an amplifier system and a current signal acquisition system with a high current resolution and a high temporal resolution for nanopore analysis. The exploration and achievements in instrument and signal processing endow nanopore techniques with reliability, affordability, and portability, which make a great leap toward its real applications.
引用
收藏
页码：4968 / 4973
页数：6
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