Current and Potential Therapies Targeting Inflammation in NASH

被引：31

作者：

Albhaisi, Somaya ^{[1
]}

Noureddin, Mazen ^{[2
]}

机构：

[1] Virginia Commonwealth Univ, Dept Internal Med, Richmond, VA 23298 USA

[2] Cedars Sinai Med Ctr, Comprehens Transplant Ctr, Karsh Div Gastroenterol & Hepatol, Los Angeles, CA 90048 USA

来源：

FRONTIERS IN ENDOCRINOLOGY | 2021年 / 12卷

关键词：

non-alcoholic steatohepatitis; inflammation; treatment; macrophages; lymphocytes; cytokines; hepatocellular injury; oxidative stress; FATTY LIVER-DISEASE; NONALCOHOLIC STEATOHEPATITIS PATIENTS; FARNESOID X RECEPTOR; EXTRACELLULAR VESICLES; S-ADENOSYLMETHIONINE; DIAGNOSTIC-ACCURACY; HEPATIC STEATOSIS; NATURAL-HISTORY; VITAMIN-D; FIBROSIS;

D O I：

10.3389/fendo.2021.767314

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Nonalcoholic steatohepatitis (NASH) is the advanced form of nonalcoholic fatty liver disease (NAFLD). It is characterized by hepatic steatosis, inflammation, hepatocellular injury, and fibrosis. Inflammation plays a key role in the progression of NASH and can be provoked by intrahepatic (e.g., lipotoxicity, immune responses, oxidative stress and cell death) and extrahepatic sources (adipose tissue or gut). The identification of triggers of inflammation is central to understanding the mechanisms in NASH development and progression and in designing targeted therapies that can halt or reverse the disease. In this review, we summarize the current and potential therapies targeting inflammation in NASH.

引用

收藏

页数：8

相关论文

共 50 条

[41] Current and emerging biologic therapies targeting eosinophilic disorders [J].

Pitlick, Mitchell M. ;

Li, James T. ;

Pongdee, Thanai .

WORLD ALLERGY ORGANIZATION JOURNAL, 2022, 15 (08)

[42] Oxidative Stress, Inflammation, and Autophagy: Potential Targets of Mesenchymal Stem Cells-Based Therapies in Ischemic Stroke [J].

He, Jialin ;

Liu, Jianyang ;

Huang, Yan ;

Tang, Xiangqi ;

Xiao, Han ;

Hu, Zhiping .

FRONTIERS IN NEUROSCIENCE, 2021, 15

[43] Editorial: Immune mechanisms of inflammation in NASH [J].

Hirsova, Petra ;

Revelo, Xavier S. .

FRONTIERS IN ENDOCRINOLOGY, 2022, 13

[44] Current Treatment Regimens and Promising Molecular Therapies for Chronic Hepatobiliary Diseases [J].

Durazzo, Marilena ;

Ferro, Arianna ;

Navarro-Tableros, Victor Manuel ;

Gaido, Andrea ;

Fornengo, Paolo ;

Altruda, Fiorella ;

Romagnoli, Renato ;

Moestrup, Soren K. ;

Calvo, Pier Luigi ;

Fagoonee, Sharmila .

BIOMOLECULES, 2025, 15 (01)

[45] Targeting ferroptosis alleviates methionine-choline deficient (MCD)-diet induced NASH by suppressing liver lipotoxicity [J].

Li, Xiaoya ;

Wang, Tian-Xiang ;

Huang, Xinmei ;

Li, Yue ;

Sun, Tiange ;

Zang, Shufei ;

Guan, Kun-Liang ;

Xiong, Yue ;

Liu, Jun ;

Yuan, Hai-Xin .

LIVER INTERNATIONAL, 2020, 40 (06) :1378-1394

[46] Targeting Inflammation by Anthocyanins as the Novel Therapeutic Potential for Chronic Diseases: An Update [J].

Kozlowska, Aleksandra ;

Dzierzanowski, Tomasz .

MOLECULES, 2021, 26 (14)

[47] Pharmacotherapy for NASH: Current and emerging [J].

Konerman, Monica A. ;

Jones, Jacob C. ;

Harrison, Stephen A. .

JOURNAL OF HEPATOLOGY, 2018, 68 (02) :362-375

[48] Potential therapies targeting nuclear metabolic regulation in cancer [J].

Chen, Yanjie ;

Xu, Jie ;

Liu, Xiaoyi ;

Guo, Linlin ;

Yi, Ping ;

Cheng, Chunming .

MEDCOMM, 2023, 4 (06)

[49] Potential therapies for HCC involving targeting the ferroptosis pathway [J].

Li, Denghui ;

Zhang, Mengjie ;

Liu, Ju ;

Li, Zhifang ;

Ni, Bing .

AMERICAN JOURNAL OF CANCER RESEARCH, 2024, 14 (04) :1446-1465

[50] Targeting Extracellular RNA Mitigates Hepatic Lipotoxicity and Liver Injury in NASH [J].

Tewari, Archana ;

Rajak, Sangam ;

Raza, Sana ;

Gupta, Pratima ;

Chakravarti, Bandana ;

Srivastava, Jyotika ;

Chaturvedi, Chandra P. P. ;

Sinha, Rohit A. A. .

CELLS, 2023, 12 (14)

← 1 2 3 4 5 →