Preparation and characterization of lipid microcapsules coated with SiO2@Al2O3 core-shell nanoparticles as carries for lipophilic drug delivery

被引：10
|
作者：
Koroleva, Marina [1 ]
Gorbachevski, Oleg [1 ]
Yurtov, Evgeny [1 ]
机构：
[1] Mendeleev Univ Chem Technol, Miusskaya Sq 9, Moscow 125047, Russia
来源：
MATERIALS CHEMISTRY AND PHYSICS | 2017年 / 202卷
基金：
俄罗斯基础研究基金会;
关键词：
Solid lipid particle; Silica nanoparticle; Emulsion; Microcapsule; Drug delivery; DOPED SILICA NANOPARTICLES; PICKERING EMULSIONS; SURFACTANT; STABILITY; POLYMER; ENCAPSULATION; NANOCAPSULES; PACLITAXEL; PARTICLES; RELEASE;
D O I：
10.1016/j.matchemphys.2017.08.065
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Solid lipid microparticles coated by silica nanoparticles and loaded with lipophilic drugs: curcumin; hydrocortisone, nimesulide or alpha-tocopherol were investigated. Complex stabilization of paraffin micro particles was achieved through the formation of steric multicomponent adsorption layer of surfactant Eumulgin O10, polyvinyl alcohol (PVA), and SiO2@Al2O3 core-shell nanoparticles, which provided protective action and steric hindrance to coalescence before paraffin solidification and to aggregation after paraffin solidification. Lipid particles with sizes in the range from 365 to 700 nm were produced using the combined effect of three types of stabilizer. High encapsulation efficiency was demonstrated; almost all the amounts of drugs were encapsulated in paraffin microcapsules. The results indicate that paraffin microparticles coated with silica nanoparticles are promising for application as delivery systems for lipophilic compounds. (C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码：1 / 6
页数：6
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