Tandem Synthesis of 1,3-Disubstituted Naphthalenes via TfOH-Promoted Directed-Aldol and Friedel-Crafts Reactions

被引：11
作者：
Li, Hongchen [1 ]
Shan, Lidong [1 ]
Min, Lin [1 ]
Weng, Yunxiang [1 ]
Wang, Xinyan [1 ]
Hu, Yuefei [1 ]
机构：
[1] Tsinghua Univ, Dept Chem, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Minist Educ, Beijing 100084, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 86卷 / 21期
基金：
中国国家自然科学基金;
关键词：
TRIFLUOROMETHANESULFONIC ACID; REGIOSELECTIVE SYNTHESIS; CARBONYL-COMPOUNDS; DERIVATIVES; CYCLIZATION; ANNULATION; KETONES; ALKYNES; BOND;
D O I：
10.1021/acs.joc.1c01713
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A TfOH-promoted tandem synthesis of 1,3-disubstituted naphthalenes is developed via a directed-aldol reaction and a Friedel-Crafts reaction. Two new C-C bonds and one new benzene ring are created efficiently in one pot due to the discovery of a TfOH-promoted highly chemoselective directed-aldol reaction between two different ketones with alpha-hydrogens.
引用
收藏
页码：15011 / 15019
页数：9
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