Effects of melatonin on cardiovascular risk factors and metabolic syndrome: a comprehensive review

被引：53
作者：
Imenshahidi, Mohsen [1 ,2 ]
Karimi, Golamreza [1 ,2 ]
Hosseinzadeh, Hossein [1 ,2 ]
机构：
[1] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Razavi Khorasan, Iran
[2] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Razavi Khorasan, Iran
来源：
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY | 2020年 / 393卷 / 04期
关键词：
Cardiovascular risk factors; Melatonin; Hypertension; Diabetes; Obesity; Metabolic syndrome; ISCHEMIA-REPERFUSION INJURY; SUSTAINED-RELEASE MELATONIN; HIGH-FAT DIET; BLOOD-PRESSURE; ENDOTHELIAL DYSFUNCTION; MYOCARDIAL-ISCHEMIA; OXIDATIVE STRESS; ARTERIAL-HYPERTENSION; GLUCOSE-METABOLISM; CARDIAC INJURY;
D O I：
10.1007/s00210-020-01822-4
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Melatonin, as a neuroendocrine hormone, is produced primarily by the pineal gland. Melatonin, a pleotropic molecule, acts as a free radical scavenger, antioxidant, and regulator of circadian rhythm in mammals via several receptor-mediated and non-receptor-mediated mechanisms. This inexpensive, well-tolerated, and multi-target molecule has a great therapeutic potential against many diseases. Many evidences have proposed that melatonin plays a key role in the pathophysiology of various cardiovascular diseases. The aim of this paper is to discuss the data and experiments regarding the effects of melatonin in management of cardiovascular risk factors. PubMed, EMBASE, and Scopus have been searched for data collection using related keywords. Two hundred ten articles were included in this review from 2253 founded documents. Using these documents, the main mechanisms of action of melatonin are discussed and summarized in this article. Also, recent progresses regarding melatonin's effects on cardiovascular risk factors and diseases including diabetes, hypertension, hyperlipidemia, obesity, myocardial ischemia-reperfusion injury, pulmonary hypertension, and atherosclerosis have been reviewed. Many studies have demonstrated the beneficial effects of melatonin in prevention and improving cardiovascular risk factors, and this inexpensive and well-tolerated drug can be strongly proposed in different cardiovascular diseases as well as metabolic syndrome.
引用
收藏
页码：521 / 536
页数：16
相关论文
共 149 条
[1]   Extrapineal melatonin: sources, regulation, and potential functions [J].
Acuna-Castroviejo, Dario ;
Escames, Germaine ;
Venegas, Carmen ;
Diaz-Casado, Maria E. ;
Lima-Cabello, Elena ;
Lopez, Luis C. ;
Rosales-Corral, Sergio ;
Tan, Dun-Xian ;
Reiter, Russel J. .
CELLULAR AND MOLECULAR LIFE SCIENCES, 2014, 71 (16) :2997-3025
[2]  
Ahmad Hajam Younis, 2018, Pak J Biol Sci, V21, P423, DOI 10.3923/pjbs.2018.423.431
[3]   The effects of melatonin supplementation on blood pressure in patients with metabolic disorders: a systematic review and meta-analysis of randomized controlled trials [J].
Akbari, Maryam ;
Ostadmohammadi, Vahidreza ;
Mirhosseini, Naghmeh ;
Lankarani, Kamran B. ;
Tabrizi, Reza ;
Keshtkaran, Zahra ;
Reiter, Russel J. ;
Asemi, Zatollah .
JOURNAL OF HUMAN HYPERTENSION, 2019, 33 (03) :202-209
[4]   Pleiotropic protective roles of melatonin against aluminium-induced toxicity in rats [J].
Allagui, Mohamed S. ;
Hachani, Rafik ;
Saidi, Saber ;
Feriani, Anouer ;
Murat, Jean C. ;
Kacem, Kamel ;
El Feki, Abdelfatteh .
GENERAL PHYSIOLOGY AND BIOPHYSICS, 2015, 34 (04) :415-424
[5]   MTNR1B G24E Variant Associates With BMI and Fasting Plasma Glucose in the General Population in Studies of 22,142 Europeans [J].
Andersson, Ehm A. ;
Holst, Birgitte ;
Sparso, Thomas ;
Grarup, Niels ;
Banasik, Karina ;
Holmkvist, Johan ;
Jorgensen, Torben ;
Borch-Johnsen, Knut ;
Egerod, Kristoffer L. ;
Lauritzen, Torsten ;
Sorensen, Thorkild I. A. ;
Bonnefond, Amelie ;
Meyre, David ;
Froguel, Philippe ;
Schwartz, Thue W. ;
Pedersen, Oluf ;
Hansen, Torben .
DIABETES, 2010, 59 (06) :1539-1548
[6]   In response to the comments on our recently published paper entitled "on the mechanisms of melatonin in protection of aluminum phosphide cardiotoxicity" [J].
Asghari, Mohammad Hossein ;
Moloudizargari, Milad ;
Abdollahi, Mohammad .
ARCHIVES OF TOXICOLOGY, 2017, 91 (10) :3457-3458
[7]   Melatonin Decreases Pulmonary Vascular Remodeling and Oxygen Sensitivity in Pulmonary Hypertensive Newborn Lambs [J].
Astorga, Cristian R. ;
Gonzalez-Candia, Alejandro ;
Candia, Alejandro A. ;
Figueroa, Esteban G. ;
Canas, Daniel ;
Ebensperger, German ;
Reyes, Roberto V. ;
Llanos, Anibal J. ;
Herrera, Emilio A. .
FRONTIERS IN PHYSIOLOGY, 2018, 9
[8]   Melatonin stimulates glucagon secretion in vitro and in vivo [J].
Baehr, Ina ;
Muehlbauer, Eckhard ;
Schucht, Helena ;
Peschke, Elmar .
JOURNAL OF PINEAL RESEARCH, 2011, 50 (03) :336-344
[9]   Role of melatonin in blood pressure regulation: An adjunct anti-hypertensive agent [J].
Baker, Jacquie ;
Kimpinski, Kurt .
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2018, 45 (08) :755-766
[10]   Diabetes-mediated myelopoiesis and the relationship to cardiovascular risk [J].
Barrett, Tessa J. ;
Murphy, Andrew J. ;
Goldberg, Ira J. ;
Fisher, Edward A. .
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 2017, 1402 (01) :31-42
12345678910