Clinical outcomes of splenectomy in children: Report of the splenectomy in congenital hemolytic anemia registry

被引：29

作者：

Rice, Henry E. ^{[1
]}

Englum, Brian R. ^{[1
]}

Rothman, Jennifer ^{[1
]}

Leonard, Sarah ^{[1
]}

Reiter, Audra ^{[1
]}

Thornburg, Courtney ^{[1
]}

Brindle, Mary ^{[2
]}

Wright, Nicola ^{[2
]}

Heeney, Matthew M. ^{[3
]}

Smithers, Charles ^{[3
]}

Brown, Rebeccah L. ^{[4
]}

Kalfa, Theodosia ^{[4
]}

Langer, Jacob C. ^{[5
]}

Cada, Michaela ^{[5
]}

Oldham, Keith T. ^{[6
]}

Scott, J. Paul ^{[6
]}

St Peter, Shawn ^{[7
]}

Sharma, Mukta ^{[7
]}

Davidoff, Andrew M. ^{[8
]}

Nottage, Kerri ^{[8
]}

Bernabe, Kathryn ^{[9
]}

Wilson, David B. ^{[9
]}

Dutta, Sanjeev ^{[10
]}

Glader, Bertil ^{[10
]}

Crary, Shelley E. ^{[11
]}

Dassinger, Melvin S. ^{[11
]}

Dunbar, Levette ^{[12
]}

Islam, Saleem ^{[12
]}

Kumar, Manjusha ^{[13
]}

Rescorla, Fred ^{[13
]}

Bruch, Steve ^{[14
]}

Campbell, Andrew ^{[14
]}

Austin, Mary ^{[15
]}

Sidonio, Robert ^{[16
]}

Blakely, Martin L. ^{[16
]}

机构：

[1] Duke Univ, Med Ctr, Durham, NC 27710 USA

[2] Alberta Childrens Prov Gen Hosp, Calgary, AB, Canada

[3] Childrens Hosp, Boston, MA 02115 USA

[4] Cincinnati Childrens Med Ctr, Cincinnati, OH USA

[5] Hosp Sick Children, Toronto, ON M5G 1X8, Canada

[6] Med Coll Wisconsin, Milwaukee, WI 53226 USA

[7] Childrens Mercy Hosp, Kansas City, MO 64108 USA

[8] St Jude Childrens Res Hosp, Memphis, TN 38105 USA

[9] St Louis Childrens Hosp, St Louis, MO 63178 USA

[10] Stanford Univ, Palo Alto, CA 94304 USA

[11] Univ Arkansas, Little Rock, AR 72204 USA

[12] Univ Florida, Gainesville, FL USA

[13] Indiana Univ, Indianapolis, IN 46204 USA

[14] Univ Michigan, Ann Arbor, MO USA

[15] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

[16] Vanderbilt Univ, Nashville, TN 37235 USA

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 2015年 / 90卷 / 03期

基金：

美国国家卫生研究院;

关键词：

HEALTH-CARE; HEREDITARY;

D O I：

10.1002/ajh.23888

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The outcomes of children with congenital hemolytic anemia (CHA) undergoing total splenectomy (TS) or partial splenectomy (PS) remain unclear. In this study, we collected data from 100 children with CHA who underwent TS or PS from 2005 to 2013 at 16 sites in the Splenectomy in Congenital Hemolytic Anemia (SICHA) consortium using a patient registry. We analyzed demographics and baseline clinical status, operative details, and outcomes at 4, 24, and 52 weeks after surgery. Results were summarized as hematologic outcomes, short-term adverse events (AEs) (30 days after surgery), and long-term AEs (31-365 days after surgery). For children with hereditary spherocytosis, after surgery there was an increase in hemoglobin (baseline 10.1 +/- 1.8 g/dl, 52 week 12.8 +/- 1.6 g/dl; mean +/- SD), decrease in reticulocyte and bilirubin as well as control of symptoms. Children with sickle cell disease had control of clinical symptoms after surgery, but had no change in hematologic parameters. There was an 11% rate of short-term AEs and 11% rate of long-term AEs. As we accumulate more subjects and longer follow-up, use of a patient registry should enhance our capacity for clinical trials and engage all stakeholders in the decision-making process. Am. J. Hematol. 90:187-192, 2015. (c) 2014 Wiley Periodicals, Inc.

引用

页码：187 / 192

页数：6

共 40 条

[1] Indications and complications of splenectomy for children with sickle cell disease [J].