Increased serum C-reactive protein is an adverse prognostic factor in low-risk myelodysplastic syndromes

被引:7
作者
Baba, Yuta [1 ,2 ]
Saito, Bungo [1 ]
Shimada, Shotaro [1 ]
Sasaki, Yohei [1 ]
Fujiwara, Shun [1 ]
Arai, Nana [1 ]
Kawaguchi, Yukiko [1 ]
Kabasawa, Nobuyuki [2 ]
Tsukamoto, Hiroyuki [2 ]
Uto, Yui [1 ]
Yanagisawa, Kouji [1 ]
Hattori, Norimichi [1 ]
Harada, Hiroshi [2 ]
Nakamaki, Tsuyoshi [1 ]
机构
[1] Showa Univ, Sch Med, Dept Med, Div Hematol,Shinagawa Ku, 1-5-8 Hatanodai, Tokyo 1428666, Japan
[2] Showa Univ, Fujigaoka Hosp, Div Hematol, Dept Med,Aoba Ku, 1-30 Fujigaoka, Yokohama, Kanagawa 2278501, Japan
关键词
C-reactive protein; Myelodysplastic syndromes; Prognosis; Inflammation; CLONAL HEMATOPOIESIS; SCORING SYSTEM; MUTATIONS; CELLS; IPSS;
D O I
10.1007/s12185-021-03187-7
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Inflammatory cytokines play a role in hematopoiesis and development of myelodysplastic syndromes (MDS). Although increased serum levels of inflammatory cytokines are associated with poor survival in MDS patients, clinical management does not include assessment of inflammation. We investigated the significance of inflammation in MDS using serum C-reactive protein (CRP) levels, an indicator of the degree of systemic inflammation that can be used in routine practice. We hypothesized that serum CRP levels can be used to further classify low-risk MDS. We conducted a retrospective analysis of 90 patients with low-risk MDS, defined by the international prognostic scoring system (IPSS). We examined the prognostic relevance of CRP and known prognostic factors at diagnosis. Increased serum CRP (>= 0.58 mg/dL) was associated with poor survival (hazard ratio [HR]: 17.63, 95% confidence interval [CI] 5.83-53.28, P < 0.001) both overall and among the 73 patients with low-risk MDS as defined by the revised IPSS (HR: 28.05, 95% CI 6.15-128.04, P < 0.001). Increased CRP might predict poor prognosis and serum CRP levels can indicate clonal hematopoiesis and non-hematological comorbidity in patients with low-risk MDS.
引用
收藏
页码:441 / 448
页数:8
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