Uncertainty propagation and sensitivity analysis: results from the Ocular Mathematical Virtual Simulator

被引：5

作者：

Prud'homme, Christophe ^{[1
]}

Sala, Lorenzo ^{[2
]}

Szopos, Marcela ^{[3
]}

机构：

[1] Univ Strasbourg, IRMA UMR CNRS 7501, F-67000 Strasbourg, France

[2] Ctr Rech INRIA Paris, F-75012 Paris, France

[3] Univ Paris, MAP5 UMR CNRS 8145, F-75006 Paris, France

来源：

MATHEMATICAL BIOSCIENCES AND ENGINEERING | 2021年 / 18卷 / 03期

关键词：

predictive ocular vascular dynamics; computational model; sensitivity analysis; ocular mathematical virtual simulator; Sobol index analysis; uncertainty quantification; DIASTOLIC BLOOD-PRESSURE; CENTRAL RETINAL ARTERY; INTRAOCULAR-PRESSURE; MODEL; GLAUCOMA; FLOW; PERFUSION; VELOCITY;

D O I：

10.3934/mbe.2021105

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We propose an uncertainty propagation study and a sensitivity analysis with the Ocular Mathematical Virtual Simulator, a computational and mathematical model that predicts the hemodynamics and biomechanics within the human eye. In this contribution, we focus on the effect of intraocular pressure, retrolaminar tissue pressure and systemic blood pressure on the ocular posterior tissue vasculature. The combination of a physically-based model with experiments-based stochastic input allows us to gain a better understanding of the physiological system, accounting both for the driving mechanisms and the data variability.

引用

页码：2010 / 2032

页数：23

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